Results 61 to 70 of about 56,761 (237)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Psychiatry InternationalHeightened anxiety can impair perceptual-motor performance, with detrimental effects potentially arising, in part, from threat-related attentional biases and interpretations.
Natsuki Sakemoto, Hideyuki Tanaka
doaj +1 more source
, 2011 Real time and non invasive, the ultrasound imag- ing modality can easily be used in minimally invasive surgery or needle insertion procedures to visualize an organ or a tumor to reach. However the manual stabilization of the ultrasound image while the organ moves with patient breathing or heart beating can be very tricky.
Nadeau, C., Krupa, A.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Multiple Time Intervals of Visual Events Are Represented as Discrete Items in Working Memory
Frontiers in Psychology, 2018 Previous studies on time perception and temporal memory have focused primarily on single time intervals; it is still unclear how multiple time intervals are perceived and maintained in working memory.
Zhiwei Fan, Yuko Yotsumoto
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Frontiers in Psychology, 2016 Human vision is organized in discrete processing episodes (e.g. eye fixations or task-steps). Object information must be transmitted across episodes to enable episodic short-term recognition: recognizing whether a current object has been seen in a ...
Christian H. Poth, Werner X. Schneider
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
No evidence for mnemonic modulation of interocularly suppressed visual input
NeuroImage, 2020 Visual working memory (VWM) allows for keeping visual information available for upcoming goal-directed behavior, while new visual input is processed concurrently. Interactions between the mnemonic and perceptual systems cause VWM to affect the processing
Surya Gayet +6 more
doaj +1 more source