Results 61 to 70 of about 3,782,308 (306)

Ventral-stream-like shape representation: from pixel intensity values to trainable object-selective COSFIRE models [PDF]

, 2014
The remarkable abilities of the primate visual cortex have inspired the construction of computational models of some visual neurons. We propose a trainable hierarchical object recognition model, which we call S-COSFIRE (S stands for Shape and COSFIRE ...
Petkov, Nicolai, George eAzzopardi, George Azzopardi, Petkov, N., Nicolai Petkov, Azzopardi, George, Azzopardi, George; id_orcid, Nicolai ePetkov, Azzopardi, G.   +8 more
core   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Martin Amis and ‘the Nature of the Offence’: from Expressions of Outrage to the Experience of Scandal

Études Britanniques Contemporaines, 2013
Martin Amis’s choice of topic for Time’s Arrow seems to confirm his reputation as a controversial figure and to turn the novel into material for explosive debate.
Diane Leblond
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Intention and motor representation in purposive action [PDF]

, 2014
Are there distinct roles for intention and motor representation in explaining the purposiveness of action? Standard accounts of action assign a role to intention but are silent on motor representation.
Butterfill, Stephen A., Sinigaglia, Corrado, C. Sinigaglia, S. A. Butterfill   +3 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Changing the Concept of Teaching English in Novice English Teachers Through Attentive Teaching

Education Sciences
This study investigated conceptual change in novice English teachers’ understanding of English teaching fostered through an Attentive Teaching-based professional development course.
Yaron Schur, Shira Farby
doaj   +1 more source

Schematic Visual Representation of Exponentiation [PDF]

Revija za Elementarno Izobraževanje, 2015
Visualization of mathematical concepts is an effective learning and teaching strategy. Within mathematics lessons, visualisation is mostly present at iconic level, where concepts are graphically represented.
Darja Antolin, Urška Lipovec
doaj