Results 41 to 50 of about 1,205,804 (266)

Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions

eLife, 2023
Across species, the optokinetic reflex (OKR) stabilizes vision during self-motion. OKR occurs when ON direction-selective retinal ganglion cells (oDSGCs) detect slow, global image motion on the retina.
Scott C Harris, Felice A Dunn
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Parallel Adaptation to Spatially Distinct Distortions

Frontiers in Psychology, 2020
Optical distortions as a visual disturbance are inherent in many optical devices such as spectacles or virtual reality headsets. In such devices, distortions vary spatially across the visual field.
Yannick Sauer, Siegfried Wahl, Siegfried Wahl, Katharina Rifai, Katharina Rifai   +4 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

A high-saturated, long-chain fatty acid ketogenic diet negatively impacts visual and motor-sensory function in a pre-clinical model of multiple sclerosis

Frontiers in Immunology
IntroductionMultiple sclerosis (MS) is a neurodegenerative condition that results in demyelination of the central nervous system. Visual impairment, retinal nerve fiber layer thinning, and impaired electrical function in retinal ganglion cells are seen ...
Erin N. Capper, Erin N. Capper, Jeffrey J. Anders, Jeffrey J. Anders, Jeffrey J. Anders, Benjamin W. Elwood, Benjamin W. Elwood, Randy H. Kardon, Randy H. Kardon, Oliver W. Gramlich, Oliver W. Gramlich, Oliver W. Gramlich, Oliver W. Gramlich   +12 more
doaj   +1 more source

Life History and Sociality Predict Variation in Eye Size across Birds

Birds, 2023
Over evolutionary times, the eye has acquired several adaptations to improve feeding efficiency and reduce predation pressure. Eye size, in particular, represents a target for selection, as it affects light capture and image resolution. Previous research
Guy Beauchamp
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

An Investigation of the Efficiency of Sensory Systems Involved in Postural Control in Deaf Athletes and Non-Athletes [PDF]

Sport Sciences and Health Research, 2015
The current study aimed at investigating the efficiency of visual, vestibular and somatic sensory systems in postural control of deaf athletes and non-athletes.
Mohammadreza Seyedi, Foad Seidi, عباس رحیمی, Hooman Minoonejad   +3 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source