Results 51 to 60 of about 7,551,855 (242)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Understanding and applying visual thinking in a doctoral context [PDF]
, 2001 This paper is an account of a study conducted to collect experiential responses from the design field to develop a transparent definition of the role of intuition and it’s place in decision making for designers.
Baxter, Seaton H., Valentine, Louise
core
, 2018 Tutkielmassa tarkastellaan Visual Thinking Strategies -menetelmän toimivuutta museovierailutilanteessa Generation -taidenäyttelyssä Jyväskylän taidemuseo Holvissa.unknown accessibilityei tietoa ...
Heikkinen, Henna
core +1 more source
A case study of the perceived influence of visual thinking strategies on teacher practice [PDF]
, 2022 The purpose of this study was to explore the influence of the use of visual thinking strategies (VTS) on teachers’ perceptions of their general teaching practice.
Connors, Christina Beatrice
core +2 more sources
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Visual Thinking Strategies in Nursing: a systematic review
Senses and Sciences, 2016 It is generally accepted that the main skills a nurse should have are communication, critical thinking, responsibility, accountability for their decision and action, attention to detail and adaptability. Nurse educators are called to prepare students to
Sara De Santis +3 more
doaj
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source