Results 321 to 330 of about 4,045,707 (379)

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Monitoring patients and asymptomatic carriers with hereditary transthyretin amyloidosis: regional protocol of Emilia-Romagna ATTR working group. [PDF]

Front Neurol
Guaraldi P, Allegri I, Ariatti A, Baldini T, Barbieri A, Barocelli F, Bartolotti M, Biagini E, Bianchi F, Borghi A, Borghi C, Boriani G, Cani I, Carigi S, Codeluppi L, Currò Dossi M, Dalpozzo F, D'Angelo R, De Gennaro R, Di Spigno F, Gardini E, Lanati G, Leuzzi C, Marzo F, Masullo M, Mazzanti G, Merli E, Milandri A, Monari D, Perugini E, Ponziani A, Postiglione E, Rasia M, Rinaldi R, Scancarello D, Serafini K, Serenelli M, Sguazzotti M, Siena E, Simone AM, Terracciano C, Valenti C, Vitale G, Vitiello M, Longhi S.   +44 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Mapping the Scientific Landscape Between Respiratory Conditions and Costs: A Bibliometric Analysis. [PDF]

Healthcare (Basel)
Lampropoulos IC, Malli F, Aggelopoulos E, Tsameti A, Rouka E, Daniil Z, Gourgoulianis KI.   +6 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Assessing the long-term persistence of SARS-CoV-2 in Guinea: insights from post-epidemic sentinel syndromic surveillance data. [PDF]

Front Epidemiol
Kadio KJJO, Gnimadi TAC, Guichet E, Hounmenou CG, Soumah AK, Diallo H, Camara A, Camara SC, Sandouno MR, Bangoura ST, Diaby M, Richard V, Poublan J, Sidibé S, Delamou A, Camara A, Kéita AK, Delaporte E, Touré A, Afroscreen Team.   +19 more
europepmc   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Exploring the challenge of diagnosing and tracking Oropouche virus during Brazil's largest recorded dengue epidemic in 2024. [PDF]

Virol J
Farias PCS, Tudella GCN, Lopes TRR, Cardoso KRA, da Rocha Rosa L, de Jesus Loeblein FP, Roso THP, de Oliveira-Filho EF, Flores EF, Silva Júnior JVJ.   +9 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source