Results 41 to 50 of about 1,851,054 (308)

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]

, 2017
BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent, Brand-Schieber, Elimor, Cady, Roger K, Munjal, Sagar, Rapoport, Alan M, Spierings, Egilius LH   +5 more
core   +1 more source

Importancia de los acontecimientos vitales como factores de cambio en el ciclo vital

Aula, 2009
RESUMEN: A lo largo del ciclo vital, los individuos experimentan una serie de acontecimientos que, sin duda, influyen en su desarrollo individual y colectivo. Tales acontecimientos parecen introducir cambios en la vida de los sujetos. El presente trabajo
Luis MELERO MARCOS, María Luisa I. VENTOLA BARRADO   +1 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Os eventos vitais: aspectos de seus registros e inter-relação da legislação vigente com as estatísticas de saúde Vital events: aspects of vital brazilian registration and relationship between the present legislation and vital statistics

Revista de Saúde Pública, 1973
Foram estudados os registros civis desde as suas origens, salientando aspectos legislativos do Brasil, chamando a atenção para algumas implicações que a legislação a eles referente trazem às estatísticas vitais e suas repercussões em planejamento de ...
Maria Helena Silveira, Ruy Laurenti
doaj   +1 more source

Vital Statistics of Iowa in Brief, 2004 [PDF]

, 2004
This publication is an historical recording of the most requested statistics on vital events and is a source of information that can be used in further ...

core  

Forecast verification for extreme value distributions with an application to probabilistic peak wind prediction

, 2012
Predictions of the uncertainty associated with extreme events are a vital component of any prediction system for such events. Consequently, the prediction system ought to be probabilistic in nature, with the predictions taking the form of probability ...
Friederichs, Petra, Thorarinsdottir, Thordis L.   +1 more
core   +1 more source

Quantifying the impact of climate change on drought regimes using the Standardised Precipitation Index [PDF]

, 2015
The study presents a methodology to characterise short- or long-term drought events, designed to aid understanding of how climate change may affect future risk.
B Lehner, B Lloyd-Hughes, D Wilhite, D-W Kim, DGC Kirono, EJ Burke, EJ Burke, F Giorgi, H Wu, H-R Byun, IPCC, IPCC, IPCC, J Keyantash, J Sheffield, J Sheffield, JA Marengo, JH Christensen, JP Vidal, K Jenkins, K Rupa Kumar, Katie Jenkins, KT Redmond, L Vasiliades, M Weiβ, M Zhao, NB Guttman, NB Guttman, Q Mu, R Warren, R Warren, Rachel Warren, S Blenkinsop, T Barker, TD Mitchell, TD Mitchell, W Li, X Gao, X Zhang, Y Hirabayashi   +39 more
core   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

[Review of] James Diego Vigil, From Indians to Chicanos: A Sociocultural History [PDF]

, 1983
Historians are typically satisfied with pinpointing dates and describing associated events while minimizing speculation and interpretations which cannot be directly supported with evidence.
Garcia, Homer D.C.
core   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
A Ganguly, A Hellman, A Helmrich, AA Burrow, AJ Swerdlow, AT Jonstrup, AY Chen, BH Long, C Pondarré, CH Cheng, Christine E. Lehman, CM Caudill, D Mishmar, D Vane, DJ Mulvihill, E Grabczyk, E Zlotorynski, F de Vathaire, F Pelliccia, FH Drake, FM Bar, G Abdurashidova, G Capranico, GR Bignell, GR Sutherland, H Zhang, HY Wu, I Bongarzone, J Sambrook, JC Wang, JM Allan, JM Fortune, K Reddy, K Takeuchi, KR Hande, KW Gow, L Enewold, L Postow, Laura W. Dillon, LB Travis, Le Beau, Levi C. T. Pierce, LF Liu, LW Dillon, LW Dillon, M Drolet, M Gandhi, M Zuker, MB Smith, MD Been, MD Been, MF Arlt, MN Nikiforova, MS Kim, NR Lemoine, O Handt, P Boffetta, PA Smanik, R Garcia-Carbonero, R Venkitaraman, RT Hay, S Anderson, S Corbin, S Klugbauer, S McAvoy, S Tuduri, S Wada, SG Durkin, SG Durkin, SJ Froelich-Ammon, SM Jhiang, SM Vos, SN Shah, T Kohno, T Kondo, T Syrovets, TW Glover, TW Glover, Valentin V Rybenkov, X Li, Y Lin, Y Lin, YE Nikiforov, YE Nikiforov, YE Nikiforov, Yuh-Hwa Wang, Yuri E. Nikiforov   +86 more
core   +3 more sources