Results 101 to 110 of about 1,324,081 (316)
Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
Frontiers in Endocrinology, 2020 In critical illness, homeostatic corrections representing the culmination of hundreds of millions of years of evolution, are modulated by the activated glucocorticoid receptor alpha (GRα) and are associated with an enormous bioenergetic and metabolic ...
Gianfranco Umberto Meduri +2 more
doaj +1 more source
NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer
Advanced Science, EarlyView.Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen +8 more
wiley +1 more source
Using reversible computing to achieve fail-safety [PDF]
, 1997 This paper describes a fail-safe design approach that can be used to achieve a high level of fail-safety with conventional computing equipment which may contain design flaws.
Bishop, P. G.
core
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Stripe formation in bacterial systems with density-suppressed motility [PDF]
, 2012 Engineered bacteria in which motility is reduced by local cell density generate periodic stripes of high and low density when spotted on agar plates. We study theoretically the origin and mechanism of this process in a kinetic model that includes growth ...
Chenli Liu +7 more
core +2 more sources
Advanced Science, EarlyView.This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo +10 more
wiley +1 more source
Unemployment Insurance and Older Workers in the United States [PDF]
, 2008 People are living longer and healthier lives at the same time that layoffs are increasing and pension plans are being curtailed. As the era of longevity progresses, unemployment among older Americans is likely to be a growing problem.
Charlotte Muller, Oleg Volkov
core
Impact of emotional exhaustions on turnover intentions : a mediating role of organizational commitment in higher education institutes of Saudi Arabia [PDF]
, 2015 Environment, organizational culture, development/promotion policies, facilities, compensation and political issues are some of the causes of reduction in the organizational commitment and increase in the level of emotional exhaustion and development of ...
Abdallah Ahmed, Nazar Omer
core +1 more source
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source