Results 161 to 170 of about 534,959 (308)

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Estimating and projecting the number of new HIV diagnoses and incidence in Spectrum's case surveillance and vital registration tool. [PDF]

AIDS, 2019
Mahiane SG, Marsh K, Glaubius R, Eaton JW.   +3 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Contribution of deaths of despair to the Hispanic mortality advantage in the USA by person, place and time: an ecological analysis of vital registration data. [PDF]

BMJ Public Health
Trejo BG, Hernandez SM, Lazo M, Bilal U.
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Characterising the killing of girls and women in urban settings in Latin America, 2000-2019: an analysis of variability and time trends using mortality data from vital registration systems. [PDF]

BMJ Public Health
Trejo BG, Michael YL, Diez Roux AV, Sánchez BN, Sun N, Stöckl H, Vidaña-Perez D, Correa-Salazar C, Ortigoza A, de Lima Friche AA, DiCecco V, Mazariegos M, Bilal U.   +12 more
europepmc   +1 more source

Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY). [PDF]

Glob Health Action, 2019
Levira F, Newton CR, Masanja H, Odermatt P.   +3 more
europepmc   +1 more source

Innovations in Monitoring Vital Events: A scalable Intervention Using Mobile Phone SMS Support for Vital Registration Coverage\ud [PDF]

, 2013
Kabadi, Gregory S, Mwanyika, Henry, Savigny, Don de   +2 more
core  

Causes of adult deaths in developing countries : a review of data and methods [PDF]

Relatively little attention has been paid to the problem of premature adult mortality in developing countries, despite high levels of mortality in many countries - and despite the potentially severe social and economic consequences of adult deaths ...
Hayes, Richard, Lockett, Geraldine, Mertens, Thierry, Rodrigues, Laura   +3 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source