Results 51 to 60 of about 1,164,698 (290)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Vital signs monitoring system [PDF]

, 1981
A system is disclosed for monitoring vital physiological signs. Each of the system components utilizes a single hybrid circuit with each component having high accuracy without the necessity of repeated calibration.
Rinard, George A., Steffen, Dale A., Sturm, Ronald E.   +2 more
core   +1 more source

Effects of Acupressure on Pain and Vital Signs of Patients After Small Abdominal Surgeries: A Clinical Trial [PDF]

, 2012
Background: Several studies have investigated the effect of acupressure on pain and vital signs however the results are inconsistent. Either no study has been conducted on the effect of acupressure on vital signs of post-surgical patients, or it is not ...
Adib-Hajbaghery, M., Etri, M.
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Short-Term Changes in Depressive Symptoms Among Patients with Alzheimer’s Disease Following a Precision Medicine Intervention

Brain Sciences
Background/Objectives: The ReCODE (Reversal of Cognitive Decline) protocol, a precision medicine program for patients with Alzheimer’s disease (AD), has demonstrated promising results in improving cognitive function.
Rammohan V. Rao, Alan Boyd, Sho Okada, William Lipa, Lance Kelly, Christine Coward, Aida L. Bredesen, Julie Gregory, Dale E. Bredesen   +8 more
doaj   +1 more source

Vital Signs Prediction for COVID-19 Patients in ICU

Sensors, 2021
This study introduces machine learning predictive models to predict the future values of the monitored vital signs of COVID-19 ICU patients. The main vital sign predictors include heart rate, respiration rate, and oxygen saturation.
Ahmed Youssef Ali Amer, Femke Wouters, Julie Vranken, Pauline Dreesen, Dianne de Korte-de Boer, Frank van Rosmalen, Bas C. T. van Bussel, Valérie Smit-Fun, Patrick Duflot, Julien Guiot, Iwan C. C. van der Horst, Dieter Mesotten, Pieter Vandervoort, Jean-Marie Aerts, Bart Vanrumste   +14 more
doaj   +1 more source

Philanthropy and community development : the vital signs of community foundation? [PDF]

, 2016
This self-funded research builds on earlier support for the study of community foundations within philanthropy from the UK’s Economic and Social Research Council (ESRC), grant reference RES-593-25-0004.Increased funding pressures on community development
Harrow, Jenny, Jung, Tobias
core   +1 more source

A review of machine learning techniques in photoplethysmography for the non-invasive cuff-less measurement of blood pressure [PDF]

, 2020
Hypertension or high blood pressure is a leading cause of death throughout the world and a critical factor for increasing the risk of serious diseases, including cardiovascular diseases such as stroke and heart failure.
El-Hajj, C., Kyriacou, P. A.
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source