Results 211 to 220 of about 407,306 (284)

QuickStats: Sepsis-Related* Death Rates^† Among Persons Aged ≥65 Years, by Age Group and Sex - National Vital Statistics System, United States, 2021. [PDF]

MMWR Morb Mortal Wkly Rep, 2023
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

[Civil registration systems and vital statistics: ethical challenges and proposals for governanceSistemas de registro civil e estatísticas vitais: desafios éticos e propostas de governança]. [PDF]

Rev Panam Salud Publica
López Dávila LM, Sotomayor Saavedra MA, Méndez CF, Cardozo de Martínez CA, Quiroz E, Gago-Galvagno LG, Mabel Garra M, Ledesma FM, Benites Estupiñan EM, Scrigni AV, Lifschitz V, Saruwatari Zavala G, Andreau de Bennato MI, Gubert IC, Sorokin P.   +14 more
europepmc   +1 more source

QuickStats: Age-Adjusted Drug Overdose Death Rates,*^,† by State - National Vital Statistics System, United States, 2021. [PDF]

MMWR Morb Mortal Wkly Rep, 2023
europepmc   +1 more source

National Vital Statistics System Division of Vital Statistics newsletter ; October 2021

nvss-newsletter-october-2021-508.pdfInside this issue \u2013 Information about the November Vital Statistics Cooperative Program Directors Webinar; Vital Statistics Modernization Community of Practice information regarding the Vital Records Death ...

core  

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

QuickStats: Birth Rates* for Females Aged 15-19 Years, by State - National Vital Statistics System, United States, 2021. [PDF]

MMWR Morb Mortal Wkly Rep, 2022
europepmc   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

QuickStats: Age-Adjusted Rates* of Firearm-Related Homicide,^† by Race,^§ Hispanic Origin, and Sex - National Vital Statistics System, United States, 2021. [PDF]

MMWR Morb Mortal Wkly Rep, 2023
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source