Results 51 to 60 of about 1,584,866 (279)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Trends and drivers of lung cancer disease burden among residents in Jing'an District, Shanghai, from 2002 to 2021

open access: yes环境与职业医学
BackgroundLung cancer, one of the most common malignant tumors worldwide, has long ranked first in cancer incidence and mortality, posing a severe challenge to public health systems.ObjectiveTo analyze the trends in incidence, mortality, and disability ...
Qiuping WAN   +6 more
doaj   +1 more source

Modelling Bovine Granuloma Formation In Vitro upon Infection with Mycobacterium Avium Subspecies Paratuberculosis

open access: yesVeterinary Sciences, 2019
Mycobacterium avium subspecies paratuberculosis (Map) causes chronic granulomatous disease in cattle and ruminant livestock, causing substantial economic losses.
J. Hunter Rice   +3 more
doaj   +1 more source

U.S. Teenage Pregnancies, Births, and Abortions, 2010: National and State Trends by Age, Race, and Ethnicity [PDF]

open access: yes, 2014
This report contains the most recent and comprehensive statistics available -- for 2010 -- on the incidence of teenage pregnancy, birth and abortion for the United States as a whole and for individual states.
Kathryn Kost, Stanley Henshaw
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Marcos referenciais para estudos e investigações em mortalidade materna Remarks for research on maternal mortality

open access: yesRevista de Saúde Pública, 1988
Foram abordados alguns aspectos relacionados à mortalidade materna como importante problema de saúde pública, e destacados outros que devem ser levados em conta quando se estuda a mortalidade materna por meio de coeficientes, tais como: o pequeno número ...
Ruy Laurenti
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Kajian Tentang Pelaksanaan Pencatatan Sipil Ditinjau dari Perspektif UU No. 23 Tahun 2006 Tentang Administrasi Kependudukan di Kabupaten Bantul [PDF]

open access: yes, 2010
The research aims to figure out the implementation of vital statistics in Bantul Regency that in line with Law No.23/2006, to find out problems in the implementation of this vital statistics, and to define efforts done by the officials in dealing with ...
Suwarni, S. (Sri)
core  

County-Specific Net Migration by Five-Year Age Groups, Hispanic Origin, Race and Sex 2000-2010 [PDF]

open access: yes, 2013
This report documents the methodology used to prepare county-level, net migration estimates by five-year age cohorts and sex, and by race and Hispanic origin, for the intercensal period from 2000 to 2010.
Cheng, Cheng   +4 more
core   +2 more sources

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