Results 71 to 80 of about 60,694 (274)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A comparison of the effects of Ketamine-Midazolam and Ketamine-Propofol combinations on vital signs of uncooperative children with dental diseases in a crossover study with repeated measurements: The Bayesian approach [PDF]

, 2023
Tahereh Abbasi-Asl, Farid Zayeri, Erfan Ghasemi, Masoud Fallahinejad Ghajari, Narjes Amiritehranizadeh, Maryam Heydarpour Meymeh, Alireza Akbarzadeh Baghban   +6 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Vitality Theory

, 2017
Group vitality is a widely invoked construct in the study of minority language maintenance and interethnic relations. Per the original framework introduced 40 years ago, the more vitality an ethnolinguistic group perceives itself to have, the more likely that it will thrive as a collective entity in an intergroup context.
Benjamin King Smith, Martin Ehala, Howard Giles   +2 more
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Hipótesis sobre la biografía de Antonio de Torquemada y su obra literaria a partir de nuevos documentos en los archivos históricos

Philologia Hispalensis
Este estudio aporta diversa documentación sobre la familia, estudios y otras cuestiones biográficas de Antonio de Torquemada a partir del rastreo en los archivos históricos.
Jesús Fernando Cáseda Teresa
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

AFERIÇÃO DE SINAIS VITAIS: UM INDICADOR DO CUIDADO SEGURO EM IDOSOS

Texto & Contexto Enfermagem, 2015
El estudio tuvo como objetivo analizar la importancia, las barreras y beneficios percibidos por el personal de enfermería, relacionada con el registro de los parámetros de signos vitales en ancianos hospitalizados.
Cristiane Chagas Teixeira, Rafaela Peres Boaventura, Adrielle Cristina Silva Souza, Thatianny Tanferri de Brito Paranaguá, Ana Lúcia Queiroz Bezerra, Maria Márcia Bachion, Virginia Visconde Brasil   +6 more
doaj  

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source