Results 121 to 130 of about 73,709 (313)

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Nonspecific pain is a marker for hypovitaminosis D in patients undergoing evaluation for sleep disorders: a pilot study

Nature and Science of Sleep, 2013
David E McCarty,1 Aronkumar Reddy,1 Quinton Keigley,2 Paul Y Kim,1 Stephen Cohen,2 Andrew A Marino1 1Division of Sleep Medicine, Department of Neurology, Louisiana State University Health Sciences Center, 2School of Medicine, Louisiana State University ...
McCarty DE, Reddy A, Keigley Q, Kim PY, Cohen S, Marino AA   +5 more
doaj  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Possible association between vitamin D deficiency and restless legs syndrome

Neuropsychiatric Disease and Treatment, 2014
Mustafa Oran,1 Cuneyt Unsal,2 Yakup Albayrak,2 Feti Tulubas,3 Keriman Oguz,4 Okan Avci,1 Nilda Turgut,4 Recep Alp,4 Ahmet Gurel3 1Department of Internal Medicine, 2Department of Psychiatry, 3Department of Biochemistry, 4Department of Neurology, Namik ...
Oran M, Unsal C, Albayrak Y, Tulubas F, Oguz K, Avci O, Turgut N, Alp R, Gurel A   +8 more
doaj  

AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]

, 2010
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun, Byoung Gwag, Doo Im, Jae Lee, Jin Lee, Jin Shin, Joe Springer, Soo Byun, Sun Park, Sun Son, Woong Cho, Yong Lee, Young Lee   +12 more
core   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

User fees impact access to healthcare for female children in rural Zambia [PDF]

, 2002
The World Bank and International Monetary Fund favor healthcare user fees. User fees offer revenue and may decrease inappropriate care. However, user fees may deter needed care, especially in vulnerable populations.
Birbeck, GL, Chen, Q, De Vogli, R, Malama, C   +3 more
core   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal Positional Vertigo

Biomolecules
Objective: The aim was to evaluate the value of otolith-associated protein otoconin-90 (OC90) and otolin-1 in the pathogenesis research and clinical treatment of benign paroxysmal positional vertigo (BPPV).
Demet Aygun, Seyma Dumur, Mehmet Nuri Elgormus, Mehmet Serkan Alpaslan, Hafize Uzun   +4 more
doaj   +1 more source

Complete neurological recovery of spinal tuberculosis after spinal surgery and vitamin D supplementary: A case series

International Journal of Surgery Case Reports
Deaths from tuberculosis (TB) in Indonesia are nearly 200,000 per year and higher than those from COVID-19. The problems associated with spinal TB are vitamin D deficiency, neurological deficit, disruption of daily living activities and long-term anti-TB treatment (24 months).
Semita, I Nyoman, Fatmawati, Heni, Munawir, Al, Juliasih, Ni Njoman   +3 more
openaire   +2 more sources