Results 221 to 230 of about 2,758,793 (376)

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

open access: yesMacromolecular Materials and Engineering, EarlyView.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian   +2 more
wiley   +1 more source

Dabigatran and other oral antithrombotic agents for the prevention of stroke in patients with atrial fibrillation

open access: yesResearch Reports in Clinical Cardiology, 2011
Fernando D Testai, Venkatesh AiyagariSection of Neurological Critical Care and Stroke, Department of Neurology and Rehabilitation, Center for Stroke Research, University of Illinois College of Medicine, Chicago, IL, USAAbstract: Atrial fibrillation (AF ...
Testai F, Aiyagari V
doaj  

Levodopa–Entacapone–Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease – Interim Analysis of the ELEGANCE Study

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced in 2018 as a device‐aided therapy for advanced Parkinson's disease (PD). Objectives The ELEGANCE study (NCT05043103) is gathering real‐world data on long‐term efficacy, safety and patient‐reported outcomes with LECIG from 13 European countries.
Daniel Weiss   +10 more
wiley   +1 more source

Eldecalcitol improves chair-rising time in postmenopausal osteoporotic women treated with bisphosphonates

open access: yesTherapeutics and Clinical Risk Management, 2014
Jun Iwamoto,1 Yoshihiro Sato21Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: An open-label randomized controlled trial was conducted to ...
Iwamoto J, Sato Y
doaj  

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

open access: yesMed Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li   +13 more
wiley   +1 more source

Transcutaneous Tibial Nerve Stimulation for Overactive Bladder Symptoms in Parkinson's Disease: Results from a Phase II Randomized Control Trial (STRIPE)

open access: yesMovement Disorders, EarlyView.
Abstract Background Lower urinary tract symptoms (LUTS) are common Parkinson's disease (PD), causing great impact. Objective The goal was to undertake a phase II randomized control trial of transcutaneous tibial nerve stimulation (TTNS) delivered by Geko device for LUTS related to overactive bladder (OAB) in PD, an easy to use of the shelf solution ...
Matthew D. Smith   +6 more
wiley   +1 more source

Prenatal Intake of High Multivitamins or Folic Acid With or Without Choline Contributes to Gut Microbiota‐Associated Dysregulation of Serotonin in Offspring

open access: yesMolecular Nutrition &Food Research, Volume 69, Issue 9, May 2025.
Consuming too much vitamins including folic acid or not enough choline during pregnancy can disturb the gut–brain serotonergic system in adult offspring. Lactococcus, Ruminococcus, Bacteroides, and Oscillospira were associated with altered serotonergic expression and function in male and female offspring, highlighting unique gut microbiota patterns ...
Jianzhang Dong   +5 more
wiley   +1 more source

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