Results 301 to 310 of about 2,758,793 (376)

The disease‐linked R336C mutation in cystathionine β‐synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

The FEBS Journal, EarlyView.
Cystathionine β‐synthase (CBS) is an essential enzyme involved in cysteine metabolism. The mutation R336C, associated with severe homocystinuria and of high incidence in Qatar, reduces its activity. Our research shows that this mutation does not destabilize the enzyme fold but subtly alters the tautomeric equilibrium of the PLP cofactor within the ...
Carolina Conter, Reyes Núñez‐Franco, Duaa Walid Al‐Sadeq, Carmen Fernández‐Rodríguez, Naroa Goikoetxea‐Usandizaga, Gheyath K. Nasrallah, Michail Nomikos, Maria Luz Martinez‐Chantar, Alessandra Astegno, Gonzalo Jiménez‐Osés, Luis Alfonso Martínez‐Cruz   +10 more
wiley   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Reversible Severe Acute Lactic Acidosis Caused by Thiamine Deficiency in Intensive Care Unit. [PDF]

Case Rep Crit Care
Hong J, Cho D, Kim HJ, Jo J, Seong GM.
europepmc   +1 more source

Milk and plasma pharmacokinetics of single‐dose ubrogepant in healthy lactating women

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The objectives of this study were to evaluate the safety, plasma and milk pharmacokinetics, excretion in breast milk, and the relative infant dose of ubrogepant following a single oral dose. Background Ubrogepant is a calcitonin gene‐related peptide receptor antagonist approved for the acute treatment of migraine in adults ...
Ramesh R. Boinpally, Jonathan H. Smith, Eric Cohen, Joel M. Trugman   +3 more
wiley   +1 more source

Before leg pain and paraparesis are attributed to vitamin C deficiency alone, comorbidities and cocausalities must be considered and ruled out. [PDF]

Malays Fam Physician
Mehri S, Finsterer J.
europepmc   +1 more source

Fat embolism: a systematic review to facilitate the development of standardised procedures in pathology

Histopathology, Volume 86, Issue 6, Page 845-861, May 2025.
The present study can provide a comprehensive overview of the FE topic. It furnishes pathologists with an updated overview useful for clinical practice and guiding future research trends, as well as facilitating the development of standardised procedures.
Donato Morena, Matteo Scopetti, Martina Padovano, Emanuela Turillazzi, Vittorio Fineschi   +4 more
wiley   +1 more source

Advancements in multiple sclerosis

Internal Medicine Journal, EarlyView.
Abstract The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis and treatment is essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive and degenerative aspects of MS continue to pose major challenges.
Turlough Montague, James Drummond, Karl Ng, John Parratt   +3 more
wiley   +1 more source

Climate change effects in older people's health: A scoping review

Journal of Advanced Nursing, EarlyView.
Abstract Background Climate change has serious consequences for the morbidity and mortality of older adults. Objective To identify the effects of climate change on older people's health. Methods A scoping review was conducted following the Joanna Briggs Institute guidelines and the PRISMA‐ScR checklist.
Eva Mª Montoro‐Ramírez, Laura Parra‐Anguita, Carmen Álvarez‐Nieto, Gema Parra, Isabel Mª López‐Medina   +4 more
wiley   +1 more source

Psychoneuroendocrine stress response in female and male youth with major depressive disorder

Journal of Child Psychology and Psychiatry, EarlyView.
Background Exposure to psychosocial stress is one of the strongest risk factors for major depressive disorder (MDD) in youth, but underlying neurobiological mechanisms are poorly understood. Previous studies on the neuroendocrine stress response in youth with MDD are scarce, limited to cortisol, and rarely considered sex differences.
Anka Bernhard, Nikola Fann, Andreas G. Chiocchetti, Katharina Ackermann, Anne Martinelli, Christine M. Freitag   +5 more
wiley   +1 more source

Restless head syndrome: A retrospective study. [PDF]

World J Methodol
Prakash S, Vadodaria V, Chawda N, Shah CS, Prakash A.   +4 more
europepmc   +1 more source