Results 41 to 50 of about 14,161,964 (303)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A reviewed approach to vitamin D supplementation in pediatric age in Portugal

Portuguese Journal of Pediatrics
Vitamin D deficiency is a well-established cause of rickets in children and has been reported as associated to impacts on other systems and organs. Vitamin D deficiency and insufficiency are pediatric worldwide global health problems.
Carla Rêgo, Gonçalo Cordeiro-Ferreira, Maria J. Lages-Fonseca, Mariana Moura-Relvas, Ricardo Ferreira, Sofia Pinto-da Costa   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Prevalence and risk factors for vitamin C deficiency in North and South India: A two centre population based study in people aged 60 years and over [PDF]

, 2011
BackgroundStudies from the UK and North America have reported vitamin C deficiency in around 1 in 5 men and 1 in 9 women in low income groups. There are few data on vitamin C deficiency in resource poor countries.ObjectivesTo investigate the prevalence ...
K. Gupta Sanjeev, Maraini Giovanni, Ravilla D. Ravindran, Giovanni Maraini, Ravilla Thulasiraj D., John Neena, Thulasiraj D. Ravilla, John, Neena, Thulasiraj D Ravilla, Young, Ian S., R Jayanthi, S. Young Ian, Usha Chakravarthy, Chakravarthy Usha, Fletcher Astrid E., Young, Ian S, Ravilla D Ravindran, Praveen Vashist, Ravilla, Thulasiraj D, Chakravarthy, Usha, Kathryn E. Fitzpatrick, Fitzpatrick, Kathryn E, Camparini, Monica, Astrid E Fletcher, Gupta, S.K., R. Jayanthi, Maraini, G., John, N., Ravilla, T.D., Fitzpatrick Kathryn E., Fitzpatrick, K.E., Maraini, Giovanni, Camparini, M., Fletcher, Astrid E, Gupta, Sanjeev K, Monica Camparini, Kathryn E Fitzpatrick, Ravindran, Ravilla D, Neena John, Fletcher, A.E., Jayanthi, R, Sanjeev K Gupta, Ravindran, R.D., Vashist Praveen, Sanjeev K. Gupta, Vashist, Praveen, Astrid E. Fletcher, Camparini Monica, Ian S Young, Jayanthi R., Jayanthi, R., Ravindran Ravilla D., Vashist, P., Ian S. Young   +53 more
core   +2 more sources

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Prevalence of Vitamin D Deficiency in Treatment-Naïve Subjects with Chronic Pulmonary Aspergillosis

Journal of Fungi, 2020
The association of vitamin D deficiency in the pathogenesis of invasive and allergic pulmonary aspergillosis is known. Whether vitamin D deficiency is prevalent in chronic pulmonary aspergillosis (CPA) remains unknown.
Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Valliappan Muthu, Naresh Sachdeva, Sanjay Kumar Bhadada, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal   +9 more
doaj   +1 more source

Vitamin D deficiency and posterior subcapsular cataract [PDF]

, 2015
Craig J Brown,1 Faical Akaichi21The Eye Center, Fayetteville, AR, USA; 2Scotland’s Rural College, Edinburgh, UKPurpose: To evaluate risk factors associated with posterior subcapsular cataract (PSC) development and the relationship between vitamin D
Brown, CJ, Akaichi F, Akaichi, F; id_orcid, Brown CJ   +3 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evaluation of vitamin D levels in patients with chronic low back-leg pain

Acta Orthopaedica et Traumatologica Turcica, 2017
Objective: We aimed to examine the relationship between the levels of vitamin D and patients with chronic low back-leg pain (CLBLP) and to investigate its effects on pain and functional capacity.
Yalkın Çalık, Ümit Aygün
doaj   +1 more source

Prevalence of Vitamin D deficiency in treatment-naive individual consecutive cancer patients

Cancer Research, Statistics, and Treatment, 2020
Background: There is a lack of information regarding Vitamin D deficiency in treatment-naive cancer patients. Aim: The aim of this was to study the prevalence of Vitamin D deficiency in cancer patients. Objectives: The objective was to measure the extent
Avinash Pandey, Anjana Singh, Shivkant Singh   +2 more
doaj   +1 more source