Results 111 to 120 of about 98,213 (249)

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Treatment of Vitamin K Deficiency in Hemodialysis Patients - A Pilot Study Comparing Menaquinone-7 Tablets and a Vitamin K Rich Diet. [PDF]

Int J Nephrol Renovasc Dis, 2022
Lentz KA, Vahlgren J, Hansen D, Plebani M, Fusaro M, Rasmussen LM, Jakobsen J, Sloth JJ, Post Hansen H, Andersen JR.   +9 more
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach. [PDF]

Genes (Basel), 2022
Rajagopal S, Sharma A, Simlot A, Mathur P, Mehta S, Mehta S, Naravula J, Medicherla KM, Kumar A, Kanga U, Suravajhala R, Bhandari RK, Nair BG, Kishor PBK, Suravajhala P.   +14 more
europepmc   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Hemorrhagic Disease of the Newborn: Clinical Presentation and Response to treatment with Vitamin K

Gomal Journal of Medical Sciences, 2013
Background: Hemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin K deficiency. In our region most babies are delivered at home or in private clinics where vitamin K is not given in routine, leading to hemorrhagic ...
Farid Ullah Shah, Muhammad Aqeel, Jehanzeb Khan, Arshia Munir, Rahida Karim   +4 more
doaj  

Exclusively breastmilk-fed preterm infants are at high risk of developing subclinical vitamin K deficiency despite intramuscular prophylaxis at birth. [PDF]

J Thromb Haemost, 2022
Clarke P, Shearer MJ, Card DJ, Nichols A, Ponnusamy V, Mahaveer A, Voong K, Dockery K, Holland N, Mulla S, Hall LJ, Maassen C, Lux P, Schurgers LJ, Harrington DJ.   +14 more
europepmc   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Gastrointestinal bleeding due to idiopathic early onset of vitamin K deficiency bleeding in a girl baby 50 min after birth: a rare case. [PDF]

BMC Pediatr, 2022
Ringoringo HP, Tambunan KR, Ananda FK, Nawati F, Permana YN.   +4 more
europepmc   +1 more source

From Circuits to Symphonies: A Systems‐Engineering Blueprint for Multimicrobial Synthetic Biology

Advanced Science, EarlyView.
Engineering synthetic microbial consortia requires moving beyond intracellular genetic circuits toward coordinated multicellular design. A modular systems‐engineering framework is presented that integrates communication, temporal coordination, ecological structuring, and predictive modeling to guide application‐dependent consortium design ...
Miguel Fernández‐Niño, Ludger A. Wessjohann, José Manuel Guillamón, Daniela Burgos‐Toro, Silvia Moriano‐Gutiérrez, Giacomo Di Matteo, Zia‐ul Islam, Rinke van van Tatenhove‐Pel, Vanessa Rossetto Marcelino, Rodrigo Ledesma‐Amaro   +9 more
wiley   +1 more source