Results 191 to 200 of about 98,213 (249)

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Do consumers and healthcare professionals report the same adverse event differently? A paired analysis of duplicate vaccine safety reports in Norway

British Journal of Clinical Pharmacology, EarlyView.
Aim This study aimed to compare how Norwegian healthcare professionals (HCPs) and consumers reported the same adverse event (AE) following immunization with vaccines against COVID‐19 during the COVID‐19 pandemic. Specifically, we aimed to compare the extent to which HCPs and consumers reported information relevant for assessing the causal relationship ...
Tommy Emil Dzus, Johaina Sarrage, Hilde Samdal, François Montastruc, Elena Rocca   +4 more
wiley   +1 more source

Neonatal Cerebellar Hemorrhage Due to Vitamin K Deficiency. [PDF]

Dtsch Arztebl Int, 2018
europepmc   +1 more source

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Vitamin K Deficiency

Pediatrics, 1985
To the Editor.— The article by Payne and Hasegawa1 on vitamin K deficiency of the newborn correctly stresses the existence of differences between vitamin K deficiency and Coumadin effect. This has been somewhat forgotten in important studies on the mode of action of prothrombin.2-4 Modern techniques as the Echis time5 and certain ...
NATHANIEL R. PAYNE, DUANE K. HASEGAWA
openaire   +3 more sources

Vitamin K deficiency in diarrhoea

The Indian Journal of Pediatrics, 2001
The study was undertaken to determine the frequency of occurrence of vitamin K deficiency in infants with diarrhoeal illness. Infants were categorized into four groups as follows: A(acute diarrhoea), B(protracted diarrhoea) C(intractable diarrhoea) and D(healthy controls).
R, Kumar, N, Marwaha, R K, Marwaha, G, Garewal   +3 more
openaire   +2 more sources

Vitamin K Deficiency Bleeding

Advances in Neonatal Care, 2013
Vitamin K deficiency bleeding (VKDB), formerly known as hemorrhagic disease of the newborn (HDN), is a bleeding disorder in neonates that is caused by inadequate serum levels of vitamin K. Vitamin K is a nutrient essential for adequate function of the coagulation cascade.
Christopher W, Woods, Amanda G, Woods, Carmen K, Cederholm   +2 more
openaire   +2 more sources

Prophylaxis of Vitamin K Deficiency in Infancy

Pediatrics International, 1992
A prospective study was performed in Okazaki, Japan, to attempt to establish a more effective system of prophylaxis for vitamin K deficiency in infancy (VKDI). During the first year, a Normotest (Hepaplastintest) was performed in all infants at one week and at one month of age. Two mg of vitamin K was administered orally to those whose Normotest values
T, Nakagawa, T, Yazawa, K, Watanabe
openaire   +2 more sources

Vitamin K Deficiency

Vitamin K is a critical fat-soluble vitamin group that naturally exists in many forms. It has been shown to play a role in coagulation, bone health, as well as cardiovascular health. It is of clinical importance because, when deficient, it results in bleeding disorders in the neonate, which have many associated complications, and malnourished ...
Reuben Parama Iswara, Kushniel Yunus, Nalini Pati   +2 more
openaire   +2 more sources