Results 41 to 50 of about 101,853 (257)
Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a north Indian population [PDF]
, 2008 PURPOSE: To examine the association of blood antioxidants with cataract. METHODS: Cross-sectional study of people aged >or=50 years identified from a household enumeration of 11 randomly sampled villages in North India.Price, Gill M., Young, Ian S, Gupta, Sanjeev K., Murthy, Gudlavalleti V. S., Murthy, Gudlavalleti VS, Chakravarthy, Usha, Maraini, Giovanni, Fletcher, Astrid E, John, Neena, Gupta, Sanjeev K, Dherani, Mukesh, Camparini, Monica, Price, Gill M, Young, Ian S., Fletcher, Astrid E. +14 morecore +1 more sourceFlash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces
Advanced Healthcare Materials, EarlyView.This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee +17 morewiley +1 more sourceNanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging
Advanced Healthcare Materials, EarlyView.The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong +13 morewiley +1 more sourceLow vitamin D status adversely affects bone health parameters in adolescents
, 2008 Background: The effects of subclinical vitamin D deficiency on bone mineral density (BMD) and bone turnover in adolescents, especially in boys, are unclear.Objective: We aimed to investigate the relations of different stages of vitamin D status and BMD ...Cashman, Kevin D, Tom R Hill, Robson, Paula J, Kiely, Mairead, Wallace, Julie MW, Werner Dubitzky, Flynn, Albert, Dubitzky, Werner, Kevin D Cashman, Liam Murray, Paula J Robson, Julie MW Wallace, Colin A Boreham, JJ Strain, Cotter, Alice A, Albert Flynn, Mairead Kiely, Strain, J J, Boreham, Colin A, Hill, Tom R, Murray, Liam, Alice A Cotter +21 morecore +1 more sourceTransdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding [PDF]
, 2018 Vitamin K deficiency within neonates can result in vitamin K deficiency bleeding. Ensuring that newborns receive vitamin K is particularly critical in places where access to health care and blood products and transfusions is limited.Paul J. McCague, Courtney Jarrahian, Emily Gerth-Guyette, Patricia S. Coffey, Quinn, Helen L., Quinn, H.L., Gerth-Guyette, E., Ryan F. Donnelly, Gerth-Guyette, Emily, Zehrung, Darin, Annie Rein-Weston, Coffey, P.S., Aaron R.J. Hutton, Eneko Larrañeta, Jarrahian, Courtney, McCague, Paul J., Darin Zehrung, Coffey, Patricia S., Jarrahian, C., Donnelly, R.F., Rein-Weston, A., Donnelly, Ryan F., Helen L. Quinn, McCague, P.J., Zehrung, D., Larrañeta, E., Hutton, A.R.J., Rein-Weston, Annie, Larrañeta, Eneko; id_orcid, Hutton, Aaron R.J. +29 morecore +1 more sourceA Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells
Advanced Healthcare Materials, EarlyView.A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin +7 morewiley +1 more sourceShould we be giving enhanced vitamin D intakes to all?
, 2011 It is widely established that vitamin D is critical for bone health. There is also an increasing body of evidence from observational studies that low levels of vitamin D are associated with a range of other disorders, including cancer and cardiovascular ...BJ Boucher, Boucher, B. J., Witham, M. D., MD Witham +3 morecore +1 more sourceShellac‐Mediated Assembly of Nanoparticles for mRNA Delivery
Advanced Healthcare Materials, EarlyView.A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso +7 morewiley +1 more sourceGenetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development [PDF]
, 2013 Background: Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and ...Jörg Bojunga, Stéphanie Bibert (3279381), Lange, Christian M., Mullhaupt, B., Ochi Hidenori, Thomas Berg (186372), Müller Tobias, Ochi, H., David Semela (416437), Gouttenoire, J., Müllhaupt, Beat, Kenichi Morikawa (416434), Nischalke, Hans-Dieter, Ulrich Spengler (205545), Ochi, Hidenori, Lange, Christian M, Dufour, J. F., David Semela, Malinverni Raffaele, Meri Gorgievski-Hrisoho (416435), Bochud Pierre-Yves, Francesco Negro (205592), Semela, David, Beat Müllhaupt (416436), Nischalke, H. D., Chayama, Kazuaki, Bochud, P. Y., Gouttenoire Jérôme, Negro, F., Cerny, A., Zoltan Kutalik, Kazuaki Chayama (128675), Lange, Christian, Negro Francesco, Pierre-Yves Bochud, Morikawa, Kenichi, Bibert, S., Malinverni, R., Spengler, U., Bibert, Stéphanie, Moradpour, Darius, Darius Moradpour (15815), Bochud, P.Y., Dufour, J.F., Hans-Dieter Nischalke (416433), Heim Markus H., Raffaele Malinverni (316140), Jean-François Dufour, Meri Gorgievski-Hrisoho, Berg Thomas, Miki, D., Vinciguerra, Manlio, Hidenori Ochi (128649), Gorgievski-Hrisoho, M., Andreas Cerny, Dufour, Jean-François, Kazuaki Chayama, Ulrich Spengler, Heim, M. H., Muller, T., Hans-Dieter Nischalke, Francesco Negro, Gorgievski-Hrisoho, Meri, Berg, Thomas, Markus H Heim, Darius Moradpour, Chayama, K., Kenichi Morikawa, Miki Daiki, Dufour Jean-François, Pierre-Yves Bochud (205597), Daiki Miki (128628), Miki, Daiki, Raffaele Malinverni, Bojunga Jörg, Jérôme Gouttenoire, Spengler Ulrich, Berg, T., Nischalke, H.D., Hidenori Ochi, Spengler, Ulrich, Cerny Andreas, Kutalik, Z., Zoltan Kutalik (3965672), Andreas Cerny (189787), Christian M Lange, Gouttenoire, Jérôme, Dufour, Jean-François Jacques, Gorgievski, Meri, Thomas Berg, Malinverni, Raffaele, Moradpour Darius, Beat Müllhaupt, Semela David, Daiki Miki, Chayama Kazuaki, Bojunga, Jörg, Stéphanie Bibert, Gorgievski-Hrisoho Meri, Tobias Müller (163591), Swiss Hepatitis C Cohort Study Group, Christian M. Lange (316130), Bojunga, J., Kutalik Zoltan, Tobias Müller, Lange, C. M., Lange Christian M., Cerny, Andreas, Markus H. Heim (237987), Lange, C.M., Kutalik, Zoltán, Heim, M.H., Nischalke Hans-Dieter, Moradpour, D., Morikawa, K., Semela, D., Jörg Bojunga (316147), Morikawa Kenichi, Negro, Francesco, Müller, Tobias, Hiroshima Liver Study Group, Bochud, Pierre-Yves, Bibert Stéphanie, Heim, Markus H., Müllhaupt Beat, Heim, Markus H, Jérôme Gouttenoire (235184), Jean-François Dufour (5654965) +127 morecore +1 more sourceIntegrated Visible Light and Oxidant Protection Through Multifunctional Sunscreens
Advanced Healthcare Materials, EarlyView.High‐energy visible radiation (HEVR), although less energetic than UV light, penetrates deeper into the skin and contributes to photoaging, pigmentation disorders, and oxidative stress. The development of new HEVR‐targeted filters, therefore, represents not only a scientific challenge but also a pressing public health and cosmetic industry need.Beatriz Peñín, Raúl Losantos, Ignacio Funes‐Ardoiz, Diego Sampedro +3 morewiley +1 more source
