Results 41 to 50 of about 98,213 (249)

Congenital Vitamin K-Dependent Clotting Factors Deficiency Type 1: A Rare Bleeding Disorder

Dubai Medical Journal, 2020
Combined deficiency of vitamin K-dependent clotting factors is usually an acquired clinical problem, often resulting from liver disease, malabsorption or warfarin overdose. However, an inherited form of the disease is very rare.
Sura Ahmed Al-Doory, Mahmoud Ahmed Radaideh, Shafeeka Mohamed Saleh, Mohammed Ali Al Sabbah   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Assessment of Potential Biomarkers of Subclinical Vitamin K Deficiency in Patients with End-Stage Kidney Disease

Canadian Journal of Kidney Health and Disease, 2014
Background: A significant proportion of hemodialysis patients have functional, but modifiable, vitamin K deficiency. Objective: To determine the correlates of poor vitamin K status in hemodialysis patients. Design: Cross-sectional study.
Meghan J Elliott, Sarah L Booth, Wilma M Hopman, Rachel M Holden   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Perinatal influences on the uptake of newborn Vitamin K prophylaxis – a retrospective cohort study

Australian and New Zealand Journal of Public Health, 2015
Objectives: To describe rates of newborn vitamin K prophylaxis uptake according to method of administration (intramuscular [IM], oral, refused) and identify predictors for the choice of oral administration and for refusal of vitamin K prophylaxis ...
Malihah Burke, Helen Bernhardt, David M. Reith, David Barker, Roland S. Broadbent, Benjamin J. Wheeler   +5 more
doaj   +1 more source

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

Journal of Medical Science, 2016
Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification.
Jan Krzysztof Nowak, Andrzej Wykrętowicz, Patrycja Krzyżanowska, Agnieszka Górna, Jarosław Tobolski, Edyta Mądry, Jarosław Walkowiak   +6 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Late vitamin K deficiency bleeding despite intramuscular prophylaxis at birth - is there a need for additional supplementation? [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2017
Introduction/Objective. Vitamin K deficiency is common in newborn infants and without prophylaxis there is a risk of vitamin K deficiency bleeding (VKDB).
Martić Jelena, Pejić Katarina, Veljković Dobrila, Rakonjac Zorica, Kuzmanović Miloš, Mićić Dragan, Vušurović Veselin, Kalanj Jasna, Janković Borisav   +8 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Old scars, new bleeds: revisiting coagulopathy in quiescent Crohn’s disease

European Journal of Case Reports in Internal Medicine
Background: Vitamin K serves as a critical coenzyme in the gamma-carboxylation of clotting factors II, VII, IX, and X, underscoring its essential role in the coagulation cascade.
Simran Patel, Ridda Khattak, Rohan Patel, Sumukh Arun Kumar, Ajinkya R. Kulkarni   +4 more
doaj   +1 more source