Results 31 to 40 of about 42,303 (189)

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Stickler syndrome is most commonly caused by variants in COL2A1 and COL11A1 genes. The purpose of this study was to describe genetic variants and phenotypes in COL2A1 and COL11A1 Stickler syndrome. We performed a retrospective genotype–phenotype evaluation of COL2A1 and COL11A1 Stickler syndrome subjects. Thirty‐two subjects with COL2A1 and 13
Aileen G. MacLachlan, Jessica A. Kraker, Denise J. Morgan, Lisa A. Schimmenti, M. Elizabeth Hartnett, Eileen S. Hwang   +5 more
wiley   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source

Short‐Term Outcomes of Two Interventions for Patients With Active Proliferative Diabetic Retinopathy in an Urban, Safety‐Net Hospital

Health Care Science, EarlyView.
An additional weekly resident‐run panretinal photocoagulation (PRP) clinic and implementation of a high‐risk registry and appointment system were associated with a decreased wait time from proliferative diabetic retinopathy (PDR) diagnosis to PRP, increased 3‐month PRP completion rates, decreased 3‐month loss to follow‐up, and increased ophthalmology ...
Paul S. Micevych, Abu Tahir Taha, Anika Kumar, Jay M. Stewart   +3 more
wiley   +1 more source

Endophthalmitis following pars plana vitrectomy for vitreous floaters

, 2014
Christopher R Henry, Stephen G Schwartz, Harry W Flynn Jr Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA Abstract: A case of Staphylococcus caprae endophthalmitis in a young ...
Flynn Jr HW, Henry CR, Schwartz SG, Schwartz, Stephen G, Henry, Christopher R, Flynn, Harry W   +5 more
core   +1 more source

The impact of coronary artery bypass grafting on the short‐ and long‐term development and progression of diabetic retinopathy: A Danish national matched cohort study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Diabetic retinopathy (DR) is a frequent long‐term complication of diabetes. While hemodynamic changes are known risk factors for DR, the effect of coronary artery bypass grafting (CABG) on the development of DR is poorly investigated.
Lukas Greve Maschoreck, Lonny Stokholm, Frederik Nørregaard Pedersen, Nis Andersen, Jens Andresen, Toke Bek, Sebastian Dinesen, Javad Hajari, Steffen Heegaard, Kurt Højlund, Caroline Schmidt Laugesen, Ryo Kawasaki, Sören Möller, Katja Christina Schielke, Yousif Subhi, Anne Suhr Thykjær Petersen, Jakob Grauslund   +16 more
wiley   +1 more source

International multi-center study of iatrogenic retinal tears in pars plana vitrectomy [PDF]

International Journal of Ophthalmology, 2019
AIM: To study and compare the effect of different surgical settings on the development of iatrogenic retinal tears (IRT) in conventional (20-gauge) and microincisional vitrectomy. METHODS: An international retrospective comparative study of 394 patients
Omar A. Saleh, Rami A. Al-Dwairi, Hasan Mohidat, Denis Jusufbegovic, Brooke Nesmith, Yoreh Barak, Michael Mimouni, Shlomit Schaal   +7 more
doaj   +1 more source

The effect of rhegmatogenous retinal detachment on retinal oxygenation

Acta Ophthalmologica, EarlyView.
Abstract Purpose Little is known about the effects of retinal detachment on oxygen extraction from retinal vessels. The role of oxygen supply from the retinal vessels in a detached area has not previously been investigated in vivo in humans. Retinal oximetry is a non‐invasive measurement of retinal oxygen saturation.
Anne‐Sofie Petri, Sindri Traustason, Sveinn H. Hardarson, Alexander Kyhnel, Einar Stefansson, Jens F. Kiilgaard, Morten la Cour, Javad Nouri Hajari, Therese Krarup   +8 more
wiley   +1 more source

Real‐world insights on switching aflibercept dosage for enhanced outcomes in age‐related macular degeneration (RISE‐AMD): Safety data

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate real‐world safety experience with aflibercept 8 mg in a large case series of patients with neovascular age‐related macular degeneration (nAMD). Methods Due to a high proportion of patients on short treatment intervals, patients with nAMD at a Danish tertiary retina clinic were systematically switched to aflibercept 8 mg ...
Mary Graciya Karunainathan, Celine Lee, Kaweh Daniel Zohalinejad, Mads Odgaard Mæng, Nanna Würtz Fabrin, Sigurrós Jónsdóttir, Anne Kjærsgaard Hassing, Søren Kveiborg Yde, Charles C. Wykoff, Henrik Vorum, Yousif Subhi, Marie Ørskov, Lasse Jørgensen Cehofski   +12 more
wiley   +1 more source

Timing of vitrectomy for treatment of endophthalmitis after intravitreal anti-VEGF injection: a systematic literature review of case reports and series

Therapeutic Advances in Ophthalmology
Objective: To perform a systematic literature review analyzing visual outcomes of immediate, early, and delayed vitrectomy in the treatment of acute endophthalmitis after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections ...
Daniel J. Hu, Sophia Ghauri, Magdalena G. Krzystolik   +2 more
doaj   +1 more source