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In vivo models of proliferative vitreoretinopathy [PDF]
Nature Protocols, 2007 We outline current in vitro and in vivo models for experimental proliferative vitreoretinopathy (PVR) and provide a detailed protocol of our standardized in vivo PVR model. PVR is the leading cause of failed surgical procedures for the correction of rhegmatogenous retinal detachment.
David R. Hinton +5 more
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Proliferative vitreoretinopathy and chemotherapeutic agents
Survey of Ophthalmology, 1985Proliferative vitreoretinopathy (PVR) is a disease process that occurs in eyes with rhegmatogenous retinal detachments and accounts for the majority of failures following retinal detachment surgery. PVR involves the uncontrolled proliferation of non-neoplastic cells capable of forming membranes, which may occur on either surface of the retina or along ...
Joel A. Schulman, Gholam A. Peyman
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Interventions for Proliferative Vitreoretinopathy
JAMA OphthalmologyClinical QuestionWhat is the efficacy of pharmacologic interventions in preventing proliferative vitreoretinopathy?Bottom LineThere is limited high-quality evidence to support currently available pharmacological options for prevention of proliferative vitreoretinopathy.
Wilson X, Wang +2 more
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Spontaneous resolution of proliferative vitreoretinopathy
Acta Ophthalmologica, 1992Abstract A case of proliferative vitroretinopathy that spontaneously regressed, leading to reattachment of the retina, is presented. The importance of such a spontaneous resolution in terms of understanding the pathogenesis, and planning a treatment, is discussed.
Anat Loewenstein +3 more
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Current Management of Proliferative Vitreoretinopathy
Seminars in Ophthalmology, 1995The recognition of APVR and its dissection, along with the use of perfluorocarbon liquids, has greatly improved the success rate in surgery for severe PVR. In reviewing our first 71 cases using these techniques, 75% were attached with one operation and 90% were attached with one or more operations.
H. M. Lambert +3 more
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Risk factors for proliferative vitreoretinopathy
Progress in Retinal and Eye Research, 1998Proliferative vitreoretinopathy (PVR) is one of the major causes of failure in retinal detachment surgery. To prevent PVR, it is necessary to determine factors predisposing its development. In primary PVR, large retinal tears, long duration of retinal detachment, vitreous hemorrhages, aphakia and choroidal detachment were demonstrated as clinical risk ...
Manabu Mochizuki +2 more
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Management of Proliferative Vitreoretinopathy
2015Proliferative vitreoretinopathy (PVR) is the clinical syndrome associated with retinal traction and detachment in which cells with proliferative potential multiply and contract on retinal surfaces and in the vitreous compartment. PVR presents with a broad spectrum of severity ranging from subtle retinal wrinkling to a total rigid retinal detachment ...
D. Velázquez-Villoria, J. García-Arumi
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Proliferative Vitreoretinopathy Membranes
Ophthalmology, 1989Proliferative vitreoretinopathy (PVR) is the leading cause of failure after retinal detachment surgery. Therefore, both the extracellular matrix and cellular components of preretinal membranes from 23 eyes with PVR were characterized immunohistochemically. The membrane stroma was composed primarily of types I, II, and III collagen.
Janice A. Jerdan +6 more
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Prevention of Proliferative Vitreoretinopathy
2006Proliferative vitreoretinopathy (PVR) is a process of cellular proliferation, extracellular matrix deposition and membrane formation and contraction which occurs as a complication of retinal detachment [14, 44]. The accepted standardised descriptions and grading of PVR refer to the clinical condition which follows rhegmatogenous retinal detachment [40,
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