Results 151 to 160 of about 2,438 (263)

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Pharmacokinetics, effectiveness and safety of certolizumab pegol in children and adolescents with active juvenile idiopathic arthritis: 9+‐year results from a multicenter, open‐label study

Arthritis &Rheumatology, Accepted Article.
Objective To assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients 2–17 years with active pcJIA and inadequate response ...
Hermine I Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Laura Shaughnessy, Saori Shimizu, Paulette Williams, Rocío Lledó‐García, Gauri Utturkar, Baran Ufuktepe, Alberto Martini, Daniel Lovell, Nicolino Ruperto   +28 more
wiley   +1 more source

The performance of ChatGPT and other large language models on multiple‐choice questions in biomedical disciplines: A meta‐analysis

Anatomical Sciences Education, EarlyView.
Abstract While large language models (LLMs) have shown promise as learning tools for medical education, their reported accuracy on multiple‐choice questions (MCQs) varies widely across studies, necessitating synthesis. This meta‐analysis synthesizes LLM accuracy on text‐based MCQs from biomedical disciplines and USMLE Step 1‐level content and explores ...
Colleen M. Cheverko, Volodymyr Mavrych, Olena Bolgova, Fathima Raahima Riyas Mohamed, Jennifer Westrick, Lorena Juarez, Emily Rush, Kathryn A. Solka, Alison F. Doubleday, Jessica N. Byram, Robert Becker, Victoria Gomez, Brenda K. Anak Ganeng, Leslie A. Hoffman, Victoria A. Roach, Kirsten M. Brown, Nicole DeVaul, Colleen N. Garnett, Hannah L. Herriott, Rebecca S. Lufler, Jason C. Mussell, Joy Y. Balta, Michael A. Pascoe, Jason W. Middleton, Sharon Duffy, Georgina C. Stephens, Adam B. Wilson   +26 more
wiley   +1 more source

Introducing virtual microscopy at the University of Ghana during the COVID‐19 pandemic—Identifying and overcoming obstacles in a low‐resource learning environment

Anatomical Sciences Education, EarlyView.
Abstract The introduction of new educational technologies into resource‐challenged learning environments is often hindered by several factors, with the lack of infrastructure and computer hardware being only one critical aspect. The COVID‐19 pandemic required a sudden switch to online learning and accelerated the implementation of e‐learning approaches
Nii Koney‐Kwaku Koney, Smart Nana Omenako, David Nana Adjei, Benjamin Arko‐Boham, Michael Hortsch   +4 more
wiley   +1 more source

Medical students' perspectives on body donation to science within the Italian context

Anatomical Sciences Education, EarlyView.
Abstract Body donation is essential for medical education and research, supporting anatomical training and clinical competence. In Italy, national data on awareness of the legislation regulating body donation and factors shaping donation‐related decisions among healthcare trainees remain limited. This study investigated knowledge of the legal framework,
Antonietta Fazio, Giulio Vara, Veronica Moretti, Annalisa Plava, Anna Maria Billi, Alessandra Ruggeri, Giulia Adalgisa Mariani, Marilisa Quaranta, Simone Lodi, Cecilia Acuti Martellucci, Maria Alessandra Sotgiu, Valentina Di Felice, Sergio Castorina, Guido Carpino, Veronica Macchi, Rita Rezzani, Mario Rende, Andrea Montella, Lucio Cocco, Lucia Manzoli, Stefano Ratti   +20 more
wiley   +1 more source

Feasibility Study for Application of Digitized Henize Mt. Wilson Michigan Southern Sky Hα$$ \boldsymbol{\alpha} $$ Survey Low‐Dispersive Spectral Plates for Searches for Anomalous and Highly Redshifted Objects

Astronomische Nachrichten, EarlyView.
ABSTRACT The goal of this study is to confirm the feasibility of the use of digitized low dispersive MtWilson Michigan Southern Sky Hα$$ \alpha $$ survey astronomical photographic plates for modern astrophysical research. The detection of highly redshifted objects, such as early galaxies and quasars, is fundamental to understanding the universe's ...
Tauseef Ahmad Zafar, René Hudec, Marta Mara Merono Vidagany, Fehmi Mejri   +3 more
wiley   +1 more source

Combined Anterior Cruciate Ligament Reconstruction and Extra‐articular Tenodesis Using the Iliotibial Band With Femoral Press‐Fit Fixation: A Low‐Cost and Reproducible Technique

Arthroscopy Techniques, EarlyView.
Abstract The addition of a lateral extra‐articular reinforcement to anterior cruciate ligament reconstruction has been shown to enhance rotational stability and protect the intra‐articular graft. Although several techniques using the iliotibial band have been described, most rely on fixation devices that increase surgical cost and complexity.
José Leonardo Rocha de Faria, Felipe Galvão Abreu, Vitor Barion de Pádua, Valdeci Manoel de Oliveira, Rafael Erthal de Paula, Yuri Di Cavalcanti, Naasson Trindade Cavanellas, José Paulo Gabbi Aramburú Filho, João Antonio Matheus Guimarães, Geraldo da Rocha Motta Filho, Phelippe Valente Maia   +10 more
wiley   +1 more source

Arthroscopic Posterior Cruciate Ligament Reconstruction Using a Pedicled Semitendinosus Autograft Through a Trans‐Septal Approach: A Technical Note

Arthroscopy Techniques, EarlyView.
Abstract Isolated posterior cruciate ligament (PCL) ruptures are relatively uncommon among knee ligament injuries. Operative management is recommended for patients with grade III posterior knee joint laxity. The complex anatomy of the PCL, particularly its course and insertion on the femur and the tibia, makes its reconstruction technically challenging.
Ali Alayane, Vincent Marot, Dany Mouarbes, Léon Ortal, Ariane Le Cunf, Regis Pailhe, Etienne Cavaignac   +6 more
wiley   +1 more source

Research progress and clinical application of functional magnetic resonance imaging in otolaryngology-head and neck diseases. [PDF]

Front Neurol
Mao M, Chen W, Huang X.
europepmc   +1 more source