Results 191 to 200 of about 308,926 (287)

Pharmacokinetics, Effectiveness and Safety of Certolizumab Pegol in Children and Adolescents With Active Juvenile Idiopathic Arthritis: 9+‐Year Results From a Multicenter, Open‐Label Study

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients aged 2 to 17 years with ...
Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Laura Shaughnessy, Saori Shimizu, Paulette Williams, Rocío Lledó‐García, Gauri Utturkar, Baran Ufuktepe, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, the Paediatric Rheumatology International Trials Organisation (PRINTO); the Pediatric Rheumatology Collaborative Study Group (PRCSG), Hermine I. Brunner, Lyudmila Grebenkina, Irina Nikishina, Ekaterina Alexeeva, Vyacheslav Chasnyk, Carlos Abud‐Mendoza, Nadina Rubio‐Pérez, Heinrike Schmeling, María del Rocio Maldonado‐Velázquez, Diane Brown, Andrew Zeft, Esi Morgan, C. Egla Rabinovich, Daniel Kingsbury, Hulya Bukulmez, Beth Gottlieb, Thomas Griffin, Lisa Imundo, Stacey Tarvin, Earl Silverman, Alberto Martini, Daniel L. Lovell, Nicolino Ruperto   +52 more
wiley   +1 more source

Three-Dimensional Assessment of Maxillary Stability Using Customized Plates in Orthognathic Surgery: A Retrospective Cohort Study. [PDF]

Craniomaxillofac Trauma Reconstr
Aguilar L, Buratovic JPV, Ibaceta VM, Merchan F, Fuhrer A, Toledo X.   +5 more
europepmc   +1 more source

Complement Activation Linked to Type II Interferon Signaling in Still Disease

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory syndrome characterized by innate immune dysregulation. Although complement can drive inflammation, its involvement in SD remains to be defined. Thus, we aimed to assess complement activation in SD. Methods Complement was assessed using transcriptomic, proteomic, and in vitro approaches. RNA sequencing
Freya M. C. H. Huijsmans, Tabea Thalheim, Alejandra Bodelón, Greta Rogani, Lyanne J. P. M. Sijbers, Remco G. A. Erkens, Aafke de Ligt, Rianne Scholman, Aron Brinker, Gisella B. Beretta, Nienke M. Ter Haar, Thomas Vogl, Johannes Roth, Trang T. Duong, Sytze de Roock, Joost F. Swart, Deborah A. Marshall, Susanne M. Benseler, Rae S. M. Yeung, Christoph Kessel, Sebastiaan J. Vastert, Emely L. Verweyen, Jorg van Loosdregt, on behalf of the UCAN CAN‐DU/UCAN CURE Consortia and the One Child Every Child Initiative, Adam Huber, Bianca Lang, Chelsea DeCoste, Elizabeth Stringer, Suzanne Ramsey, Alan Rosenberg, Kate Neufeld, Mehul Jariwala, Tristan Kerr, Alexander Mosoiu, Alisa Rachlis, Amy Xu, Arthur Cheng, Brenleigh Jebb, Brian Feldman, Bruno Pereira, Deborah Levy, Dilan Dissanayake, Elizaveta Limenis, Evelyn Rozenblyum, Harper Cheng, Jennifer Ji Young Lee, Lynn Spiegel, Rayfel Schneider, Ronald Laxer, Ruud Verstegen, Shirley Tse, Andrea Human, David Cabral, Herman Tam, Jaime Guzman, Kim Morishita, Kristin Houghton, Lori Tucker, Mercedes Chan, Ross Petty, Tommy Gerschman, Annet van Royen‐Kerkhof, Berent Prakken, Erika Van Nieuwenhove, Marc Jansen, Nico Wulffraat, Ciarán Duffy, Nadia Luca, Roman Jurencak, Tala El Tal, Claire LeBlanc, Gaëlle Chédeville, Piya Lahiry, Rosie Scuccimarri, Sarah Campillo, Clare Hutchinson, Daniah Basodan, Dax G Rumsey, Hon Yan Ng, Jeanine McColl, Lillian Lim, Tara McGrath, Danielle Brinkman, Petra Hissink Muller, Elizabeth Legger, Wineke Armbrust, Ellen Schatorje, Esther Hoppenreijs, Elodie Boudes, Gillian Currie, Heinrike Schmeling, Muhammed Dhalla, Nicole Johnson, Paivi Miettunen, Ravneet Sran, Rebeka Stevenson, Erkan Demirkaya, Jonathan Park, Roberta Berard, Giske Biesbroek, Mariken Gruppen, Gordon Soon, Joseph Cafazzo, Liane Heale, Michelle Batthish, Tania Cellucci, Lily Lim, Maarten IJzerman, Marinka Twilt, Marleen Verkaaik, Philomine van Pelt, Sylvia Kamphuis, Michelle Kip, Nicholas Blanchette, Paul Dancey, Regina de Geus   +115 more
wiley   +1 more source

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen. [PDF]

J Pharm Pharm Sci
Sitovs A, Gurkina K, Petersone L, Mohylyuk V.   +3 more
europepmc   +1 more source

Medical students' perspectives on body donation to science within the Italian context

Anatomical Sciences Education, EarlyView.
Abstract Body donation is essential for medical education and research, supporting anatomical training and clinical competence. In Italy, national data on awareness of the legislation regulating body donation and factors shaping donation‐related decisions among healthcare trainees remain limited. This study investigated knowledge of the legal framework,
Antonietta Fazio, Giulio Vara, Veronica Moretti, Annalisa Plava, Anna Maria Billi, Alessandra Ruggeri, Giulia Adalgisa Mariani, Marilisa Quaranta, Simone Lodi, Cecilia Acuti Martellucci, Maria Alessandra Sotgiu, Valentina Di Felice, Sergio Castorina, Guido Carpino, Veronica Macchi, Rita Rezzani, Mario Rende, Andrea Montella, Lucio Cocco, Lucia Manzoli, Stefano Ratti   +20 more
wiley   +1 more source

Quantum-Inspired Adaptive Meta-Heuristic-Machine Learning framework for resilient and energy-efficient task scheduling in multi-cloud ecosystems. [PDF]

Sci Rep
Divya N, Kiranbabu MNV, Babu GC.
europepmc   +1 more source

Direct SMBH Formation Driven by Runaway Stellar Collisions in Globally Unstable Stellar Systems

Astronomische Nachrichten, EarlyView.
ABSTRACT The fueling problem addresses the ultimate fate of the reservoirs of gas and stars driven into the deepest gravitational potential wells of galaxies, thus it may contain the Universe's densest concentrations of gas and stars. This raises a key question: does the infalling material collapse directly into a supermassive black hole, or can it ...
Marcelo C. Vergara, Andrés Escala
wiley   +1 more source

Acute and Chronic Leukemia in Sub-Saharan Africa: A Systematic Review. [PDF]

Cancer Rep (Hoboken)
Ayirebi AA, Twumasi S, Olaga LK, Sackey B, Antonio DNM, Ansah RO, Ansah EA, Sah JA, Anto EO, Anang-Quartey Y, Koomson A, Opoku A, Donkor GA, Duah P, Boadu AG, Essien-Baidoo S, Boadu WIO, Boateng LA.   +17 more
europepmc   +1 more source

Combined Anterior Cruciate Ligament Reconstruction and Extra‐articular Tenodesis Using the Iliotibial Band With Femoral Press‐Fit Fixation: A Low‐Cost and Reproducible Technique

Arthroscopy Techniques, EarlyView.
Abstract The addition of a lateral extra‐articular reinforcement to anterior cruciate ligament reconstruction has been shown to enhance rotational stability and protect the intra‐articular graft. Although several techniques using the iliotibial band have been described, most rely on fixation devices that increase surgical cost and complexity.
José Leonardo Rocha de Faria, Felipe Galvão Abreu, Vitor Barion de Pádua, Valdeci Manoel de Oliveira, Rafael Erthal de Paula, Yuri Di Cavalcanti, Naasson Trindade Cavanellas, José Paulo Gabbi Aramburú Filho, João Antonio Matheus Guimarães, Geraldo da Rocha Motta Filho, Phelippe Valente Maia   +10 more
wiley   +1 more source

Defect-Engineered Floating-Gate Synapses With Programmable Relaxation Dynamics for Multi-Timescale Neuromorphic Computing. [PDF]

Small
Li C, Li L, Li Z, Zhang F, Lv C, Dong L, Zhao J.   +6 more
europepmc   +1 more source