Results 181 to 190 of about 31,978 (281)

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri   +7 more
wiley   +1 more source

Dual-sensor coherence-driven adaptive denoising (WF-VMD-DDCDO) for underwater target detection. [PDF]

open access: yesSci Rep
Qiu H   +8 more
europepmc   +1 more source

The Role of Conformational Preorganization in the Reactivity of cis‐1,2‐Dimesylate‐bis(benzyloxy)cyclooctane: An Activation Strain Perspective

open access: yesChemistryOpen, Volume 15, Issue 7, July 2026.
Selective monosubstitution in cyclooctane dimesylates is investigated by DFT calculations. Despite favorable SN2 conditions, the second substitution is suppressed due to increased activation strain and unfavorable conformational reorganization. The results reveal that intrinsic structural constraints, rather than external factors, govern reactivity ...
Selçuk Eşsiz, Emine Salamci
wiley   +1 more source

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das   +3 more
wiley   +1 more source

From extracellular entry to intracellular release: A water‐assisted transport cycle for creatine in SLC6A8

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract The creatine transporter (CRT/SLC6A8) plays a key role in cellular energy homeostasis, yet the molecular mechanism underlying creatine transport remains poorly understood. Here, we reconstruct the complete transport cycle of human CRT using a hybrid simulation strategy that combines constant‐force steered molecular dynamics (cf‐sMD) with ...
Pitambar Poudel   +2 more
wiley   +1 more source

When can AlphaFold predict the oligomeric states of proteins?

open access: yesProtein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

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