Results 141 to 150 of about 34,460 (284)

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

An Improved Sparrow Search Algorithm for the Optimization of Variational Modal Decomposition Parameters

Applied Sciences
Variational modal decomposition (VMD) is frequently employed for both signal decomposition and extracting features; however, the decomposition outcome is influenced by the quantity of intrinsic modal functions (IMFs) and the specific parameter values of ...
Haoran Du, Jixin Wang, Wenjun Qian, Xunan Zhang   +3 more
doaj   +1 more source

Confinement‐Induced Enhancement of Solid‐State Emission Quantum Yield in Rubrene@MOF Hybrid Materials

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Pore‐size‐controlled nanoconfinement of rubrene within UiO‐66 and UiO‐67 suppresses aggregation‐caused quenching and restores bright solid‐state emission. Geometric exclusion and energetic destabilization prevent parallel stacking, yielding solution‐like absorption and fluorescence quantum yields up to 25%.
Julia Larcher, Viktoria Kiefer, Manuel Ott, Armin Penz, Thomas S. Hofer, Gregor Jung, Heidi A. Reichl   +6 more
wiley   +1 more source

New 2D-Variational Mode Decomposition-Based Techniques for Seismic Attribute Enhancement

Applied Sciences
Seismic attributes are widely used to enhance the interpretation of structural, stratigraphic, and lithologic features in subsurface data. Their effectiveness, however, can be limited by noise, resolution constraints, and processing artifacts. This study
Said Gaci, Mohammed Farfour
doaj   +1 more source

Evidence of internal structure validity of the nursing outcome “Mechanical Ventilation Weaning Response: Adult (0412)” for critically ill COVID‐19 patients

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To evaluate the evidence of internal structure validity of the nursing outcome (NO) “Mechanical Ventilation Weaning Response: Adult (0412)” of the NOs classification for critically ill COVID‐19 patients. Methods A methodological study focused on internal structural validation, part of a multicenter study, was carried out in the ...
Aline Batista Maurício, Viviane Martins da Silva, Agueda Maria Ruiz Zimmer Cavalcante, Larissa Giardini Bruni, Sue Ann Moorhead, Elizabeth Swanson, Karen Dunn Lopez, Marcos Venícios de Oliveira Lopes, Alba Lucia Bottura Leite de Barros   +8 more
wiley   +1 more source

A combined model for short-term traffic flow prediction based on variational modal decomposition and deep learning

Scientific Reports
The emergence of Deep Learning provides an opportunity for traffic flow prediction. However, uncertainty and volatility exhibited by nonlinearity and instability of traffic flow pose challenges to Deep Learning models.
Chuanxiang Ren, Fangfang Fu, Changchang Yin, Li Lu, Lin Cheng   +4 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

MtDNA deletion rate in myocardium of VMD patients (mean ± SEM).

, 2014
MtDNA deletion rate in myocardium of VMD patients (mean ± SEM).
Zhi-Quan Liu (680745), Jin Wei (424761), Jian Liu (33711), Zu-Yi Yuan (680746), Deng-Feng Gao (680744), Rui Yan (424765), Hao Wang (39217), Ming-Xia Chen (680747)   +7 more
core   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source