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Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source

Nigerian Professional Female Construction Workers in Vocational Occupations: Diversification or Deviation?

Organization, Technology and Management in Construction: An International Journal, 2018
The construction industry did not just evolve on its own. It is a product of the conscious efforts of several individuals called construction workers. In Nigeria, it is a large employer of the population, skilled, unskilled, and professional.
Odubiyi Tawakalitu Bisola
doaj +1 more source

Reflecting on the nature of work in contemporary South Africa: A public theological engagement with calling and vocation

HTS Teologiese Studies/Theological Studies, 2020
This article argues for a rediscovery of a theology of work in South Africa that is based on the Protestant notion of calling and vocation. Such a view has the primary intention of emphasising obedience and faithfulness to God rather than self-fulfilment
Dion A. Forster
doaj +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn +2 more
wiley +1 more source

Personalized ideological content recommendation via reinforcement learning as a digital therapeutic for anxiety reduction in youth

Discover Artificial Intelligence
Adaptive digital therapies are needed with increasing rates of youth anxiety. However, existing systems lack personalization and dynamic learning. To solve this, the proposed research is to build a personalized ideological content recommendation model ...
Yu Wang
doaj +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

Vocational Students’ Ways of Handling the Academic/Vocational Divide

International Journal for Research in Vocational Education and Training, 2021
Purpose: The focus of this article is on Swedish vocational students’ own thoughts about different types of knowledge and how these thoughts relate to the forming of their vocational identities. The article reports on a study which investigates how vocational students handle the division between theoretical and practical knowledge as they learn to ...
openaire +6 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source

Cervical mucus proteomics approach for swamp buffalo secreted fertility biomarker identification

Journal of Veterinary Research
Reproductive efficiency in swamp buffalo (Bubalus bubalis) remains constrained by the lack of molecular tools to identify fertile females before service. The aim of this study was to discover biologically grounded biomarkers of fertility.
Yusuf Muhammad +8 more
doaj +1 more source

Die Grundzüge der Spiritualität des Ordenslebens im sechsten Kapitel in der dogmatischen Konstitution über die Kirche „Lumen gentium“

The Person and the Challenges, 2017
The article presents the basic principles of the spirituality of consecrated life as they are laid out in chapter VI of the Constitution on the Church. These principles can be summed up as the following: 1.
Mateusz Micek
doaj +1 more source

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