Results 101 to 110 of about 320,661 (291)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Personal Knowledge and Faith of a Scientist

Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica
This study intends to probe into the Christian faith of a well-known Hungarian scientist, István Hatvani (1718–1786). It does not claim to look at all of his writings by scrutinizing all of his statements about how science and Christian faith ...
Ábrahám KOVÁCS
doaj   +1 more source

editor’s introduction [PDF]

, 2019
The last issue of JNCHC (spring/summer 2019) included a Forum on “Current Challenges to Honors Education.” The essays focused on challenges to honors while this issue’s Forum addresses challenges within honors, especially the challenges we present to our
Long, Ada
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Crisis in the Life of Professionals in Pastoral Ministry

Theology and Philosophy of Education
This article presents the topic of crisis in the context of prevention in pastoral workers. It points to the possibility of coping with crisis and thus offers a theological view of overcoming it.
Jana Jičínská
doaj  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

STRATEGY TO IMPROVE SAFETY ON CARGO SHIPS [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
In sea transportation, shipping safety is the main goal. In Indonesia, the safety of shipping for commercial vessels refers to national regulations, namely the Law of the Republic of Indonesia Number 17 of 2008 concerning Shipping and international ...
Kuncowati
doaj  

Dangerous calling, the life-and-death matter of safety at sea: a collection of articles from SAMUDRA Report [PDF]

, 2003
Fishing is arguably the world's most dangerous vocation, reporting the highest rate of occupational fatalities among industries, made only worse by declining fish prices, overfished waters and shortened fishing seasons.

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