Results 91 to 100 of about 13,330 (265)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
New Vocational Paradigm: Vocational Literacy and Work Imagination in Vocational Students
Journal of Office Administration : Education and PracticeThis study explores the state of vocational literacy and work imagination among Business and Finance students at the Vocational Faculty, Universitas Negeri Yogyakarta. Improving these skills helps students design careers, define identities, develop skills, and recognize professional opportunities and challenges that they can prepare for future work ...
Joko Kumoro, Danang Setyaramadani
openaire +1 more source
Cervical mucus proteomics approach for swamp buffalo secreted fertility biomarker identification
Journal of Veterinary ResearchReproductive efficiency in swamp buffalo (Bubalus bubalis) remains constrained by the lack of molecular tools to identify fertile females before service. The aim of this study was to discover biologically grounded biomarkers of fertility.
Yusuf Muhammad +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Crisis in the Life of Professionals in Pastoral Ministry
Theology and Philosophy of EducationThis article presents the topic of crisis in the context of prevention in pastoral workers. It points to the possibility of coping with crisis and thus offers a theological view of overcoming it.
Jana Jičínská
doaj
Personal Knowledge and Faith of a Scientist
Studia Universitatis Babeş-Bolyai. Theologia Reformata TransylvanicaThis study intends to probe into the Christian faith of a well-known Hungarian scientist, István Hatvani (1718–1786). It does not claim to look at all of his writings by scrutinizing all of his statements about how science and Christian faith ...
Ábrahám KOVÁCS
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source