Results 41 to 50 of about 2,873 (215)
GamesThe digital divide between large enterprises and SMEs (Small and Medium-sized Enterprises) within industrial clusters poses a significant challenge to achieving collective digital transformation, exacerbated by the quasi-public goods, attributes of ...
Dingteng Wang +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Scientific ReportsThe rapid urbanization of cities has exacerbated traffic congestion, resulting in significant environmental impacts, including elevated greenhouse gas emissions and deteriorating air quality.
Ruokun Wang +4 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Vocation of a Doctor [PDF]
The Linacre Quarterly, 2012 Doctors are called to a life of compassionate service to human beings invested with intrinsic dignity. This essay is adapted from the commencement address that Dr. Landry delivered at the St. Louis University School of Medicine on July 18, 2011.
openaire +2 more sources
Swiss Journal of Sociology, 2017 This article draws on a long-term ethnographical survey. It aims to discuss the social conditions of possibility in the artistic calling of contemporary dancers from working class backgrounds.
Sorignet Pierre-Emmanuel
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
La correspondance de Jacques Rivière et Alain-Fournier : une aventure de la lecture
Itinéraires, 2010 Through a precise study of the letters that Jacques Rivière and Alain-Fournier wrote to each other between 1904 and 1909, when they were young men, the article uncovers a form of existential event in the very act of reading.
Julie Aucagne
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