Results 71 to 80 of about 320,661 (291)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
ORGANIZATIONAL COMPETENCES FOR THE ROMANIAN TOURISTIC FIRM AND WAYS TO CONCEIVE THEM [PDF]
Between the vocation and the competence of an organization there is a complexand a subtle relation. If the vocation it means searching and finding the need or the need typethat will be covered, the competence means to know, to want and to be capable to ...
Malina Cordos
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
explore, Spring 2003, Vol. 6, no. 2: Vocation [PDF]
, 2003 Contents: Letter from the Director; Discovering the Path: Santa Clara\u27s New Initiative on Vocation; Is Engineering My Vocation?; Vocation as Occupation, Inclination, and Parental Influence; Confessions; Vocation of Presence; An Ignatian Faculty Forum;
Ignatian Center for Jesuit Education
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Person and the Challenges, 2012 This paper sets out to explore and examine online discussions of twenty-two students pursuing the M.A. programme in Catholic School Leadership at St Mary’s University College in Twickenham, London.
David Fincham
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
'Fides quaerens intellectum practico-socialem' in the Writings of Adalbert-G. Hamman (1910-2000): Some Footnotes to the Pro-existential Attitude of the Fathers [PDF]
, 2004 The author of the article -- a qualified Hamman scholar and researcher -- delves into one of the most characteristic features of this French patristic scholar who was an expert on Christian antiquity and on early Christian prayer.
Scerri, Hector
core
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Between the Center and the Margins: Young Catholics, “Sorta-Catholics,” and Baptismal Identity
Religions, 2019 Increased pastoral and theological attention to the vocational implications of baptism is sorely needed. As a small contribution to this conversation, this article will examine the insights of young Catholics and their self-described “former ...
Rhodora Beaton
doaj +1 more source