Results 81 to 90 of about 321,436 (291)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Between the Center and the Margins: Young Catholics, “Sorta-Catholics,” and Baptismal Identity
Religions, 2019 Increased pastoral and theological attention to the vocational implications of baptism is sorely needed. As a small contribution to this conversation, this article will examine the insights of young Catholics and their self-described “former ...
Rhodora Beaton
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Boundaries and Relationships in Homelessness Work: Lola, an Agency Manager
Forum: Qualitative Social Research, 2004 The professional is also a human being. This paper explores the complementary and contradictory relation between biography and vocation in the history of a nurse who became a social work manager, as revealed in a biographic-narrative interview.
Tom Wengraf
doaj
Eminescology – a Constant Concern of the Researcher Dumitru Apetri
PhilologiaThe article reveals the contribution of the scholar and writer Dumitru Apetri to Eminescian creation and Eminescology – masterful fields of Romanian philology.
Vlad CARAMAN
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Hohol’s Anthropological Project in the Russian Empire
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen'Purpose. To reconstruct Hohol’s point of view on his anthropological project, that is, to identify his answers to the question of what a person is in the dimensions of the essential and the proper.
A. M. Malivskyi +2 more
doaj +1 more source
Dangerous calling, the life-and-death matter of safety at sea: a collection of articles from SAMUDRA Report [PDF]
, 2003 Fishing is arguably the world's most dangerous vocation, reporting the highest rate of occupational fatalities among industries, made only worse by declining fish prices, overfished waters and shortened fishing seasons.
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source