Results 61 to 70 of about 67,345 (239)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Reinterpreting Science as a Vocation [PDF]
, 2022 Weber's 'science as a vocation' has often been viewed as a therapeutic concept with no functional significance in the fully bureaucratized and professionalized modern science.
Zhang, Tong
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
La correspondance de Jacques Rivière et Alain-Fournier : une aventure de la lecture
Itinéraires, 2010 Through a precise study of the letters that Jacques Rivière and Alain-Fournier wrote to each other between 1904 and 1909, when they were young men, the article uncovers a form of existential event in the very act of reading.
Julie Aucagne
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Organization, Technology and Management in Construction: An International Journal, 2018 The construction industry did not just evolve on its own. It is a product of the conscious efforts of several individuals called construction workers. In Nigeria, it is a large employer of the population, skilled, unskilled, and professional.
Odubiyi Tawakalitu Bisola
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 1948 Article published in Mennonite Community on finding a Christian ...
Yoder, John Howard
core +1 more source
Discover Artificial IntelligenceAdaptive digital therapies are needed with increasing rates of youth anxiety. However, existing systems lack personalization and dynamic learning. To solve this, the proposed research is to build a personalized ideological content recommendation model ...
Yu Wang
doaj +1 more source
HTS Teologiese Studies/Theological Studies, 2020 This article argues for a rediscovery of a theology of work in South Africa that is based on the Protestant notion of calling and vocation. Such a view has the primary intention of emphasising obedience and faithfulness to God rather than self-fulfilment
Dion A. Forster
doaj +1 more source