Results 31 to 40 of about 137,274 (148)

Novos conhecimentos sobre a doença de Vogt-Koyanagi-Harada [PDF]

, 2009
Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals.
DAMICO, Francisco Max, BEZERRA, Felipe Theodoro, GASPARIN, Fábio, YAMAMOTO, Joyce Hisae, SILVA, Gaspar Carvalho da   +4 more
core   +1 more source

A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab

Journal of the Formosan Medical Association, 2019
Vogt-Koyanagi-Harada (VKH) disease is uncommon in the pediatric population and can have an aggressive course with serious visual sequelae. A 12-year-old Han Chinese American female, who presented with mild headaches and panuveitis with diffuse serous ...
Emily Su, Vikash S. Oza, Paul Latkany
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Vogt-Koyanagi-Harada disease: a clinical case report [PDF]

, 2023
Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Boala Vogt-Koyanagi-Harada (VKH) (sindromul uveomeningeal) se caracterizează prin uveita bilaterală și dereglări somatice generale precum ...
Magla, Tatiana, Glinca, Daniil, Porada, Serghei, Moscalciuc, Alina   +3 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Integrated quantitative proteomic, phosphoproteomic, and transcriptomic analyses of human trophoblast stem cells identify stage‐specific kinase signaling networks that regulate trophoblast self‐renewal and differentiation into syncytiotrophoblasts and extravillous trophoblasts.
Rajnish Kumar, Purbasa Dasgupta, Soma Ray, Soumen Paul   +3 more
wiley   +1 more source

A COVID-19 perspective of Vogt–Koyanagi–Harada disease

Indian Journal of Ophthalmology, 2023
Vogt–Koyanagi–Harada (VKH) disease, a bilateral granulomatous panuveitis associated with multisystem involvement, is a T-cell-mediated autoimmune disorder in which cytotoxic T-cell target melanocytes in genetically susceptible individuals.
Parthopratim Dutta Majumder, Soumen Sadhu, Julio J González-López, Manabu Mochizuki   +3 more
doaj   +1 more source

Exudative Retinal Detachments: A Rare Adverse Effect of Topiramate

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Topiramate‐induced multifocal exudative retinal detachment is a rare but potentially vision‐threatening adverse effect. We report a 59‐year‐old woman with idiopathic intracranial hypertension who developed painless bilateral blurry vision and color desaturation 8 days after initiation of topiramate 25 mg twice daily.
Sarah Aljefri, Meshal Alzakari, Bailasan Milibari, Doaa Milibari   +3 more
wiley   +1 more source

Relato de Caso: Síndrome de Vogt-Koyanagi-Harada / Case Report: Vogt-Koyanagi-Harada Syndrome [PDF]

, 2021
Vogt–Koyanagi–Harada (VKH) disease is an inflammatory and autoimmune condition characterized by panuveitis, serous retinal detachments, and extraocular manifestations of the auditory, integumentary, and central nervous systems (CNS).
Caiado, Gustavo Coelho, Dompieri, Rodrigo Crispim, Daher, Valéria Barcelos, Guimarães, Valeriana de Castro   +3 more
core   +1 more source

Solo diagnosticamos lo que conocemos: síndrome de Vogt Koyanagi-Harada (VKH)

Repertorio de Medicina y Cirugía
Objetivo: se presenta un caso de síndrome de Vogt-Koyanagi-Harada en una paciente joven sin antecedentes de importancia. Presentación del caso: paciente femenina de 23 años que consultó por cuadro clínico de 1 mes de evolución caracterizado por pérdida ...
Pablo Salomón Montes Arcón, Marco Antonio Lujan Agamez, Gloria Caterine Perez Mingan, Paola María Blanco Pertuz, Oscar Giovanny Iglesias Jiménez   +4 more
doaj   +1 more source