Results 41 to 50 of about 1,278,456 (199)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Acute interstitial nephritis and probable Vogt–Koyanagi–Harada disease following COVID-19 infection: a case report

Journal of Medical Case Reports
Introduction Vogt–Koyanagi–Harada disease is an autoimmune inflammatory disease characterized by bilateral serous retinal detachment, which viral infections might induce.
Nahid Aslani, Mohammad Malekahmadi, Alireza Merrikhi, Alaleh Gheisari, Aida Mardani, Kimia Afshar   +5 more
doaj   +1 more source

Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis

iScience
Summary: Autoimmune uveitis and posterior scleritis are ocular diseases caused by immune dysregulation. Their pathogenesis remains elusive, and delayed diagnosis can exacerbate vision loss.
Xueru Li, Jinying An, Lingzi Wu, Qingqin Tao, Hui Zhang, Xiaomin Zhang   +5 more
doaj   +1 more source

Vogt-Koyanagi-Harada syndrome presenting with encephalopathy

Annals of Indian Academy of Neurology, 2013
VogtKoyanagi-Harada (VKH) is a rare syndrome affecting tissues with melanocytes. The possibility that VKH syndrome has an autoimmune pathogenesis is supported by the high frequency of human leukocyte antigen-DR4 commonly associated with other autoimmune ...
Alireza E Naeini, Dana Daneshmand, Farzin Khorvash, Ahmad Chitsaz   +3 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Vogt-Koyanagi-Harada Syndrome

, 2022
Vogt-Koyanagi-Harada (VKH) syndrome is a rare disorder that affects several body systems. Here we take a broad look at the presentation and pathophysiology of VKH, with a more specific focus on the relevant eye findings. Since much is not known about VKH,
Shwetha Mudalegundi, Medical Student; Amanda D. Henderson, MD
core  

Isolated Posterior Atypical Presentation of Vogt-Koyanagi-Harada Syndrome in a Young Girl: A Rare Case Report

International Journal of Medical and Pharmaceutical Case Reports
Background: Vogt-Koyanagi-Harada (VKH) disease is a rare autoimmune disorder affecting melanocyte-rich tissues, including the uvea, meninges, skin, and inner ear.
L. Sbai, T. Boutaj, R. Benkirane, Z. Hilali, B. Azarkan, R. el Hachimi, L. O. Cherkaoui   +6 more
semanticscholar   +1 more source

Exudative Retinal Detachments: A Rare Adverse Effect of Topiramate

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Topiramate‐induced multifocal exudative retinal detachment is a rare but potentially vision‐threatening adverse effect. We report a 59‐year‐old woman with idiopathic intracranial hypertension who developed painless bilateral blurry vision and color desaturation 8 days after initiation of topiramate 25 mg twice daily.
Sarah Aljefri, Meshal Alzakari, Bailasan Milibari, Doaa Milibari   +3 more
wiley   +1 more source

A Systematic Review of Literature: TNF‐α Blockers and JAK Inhibitors for the Treatment of Stevens‐Johnson Syndrome, Toxic Epidermal Necrolysis, and Severe Forms of Erythema Multiforme

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Stevens‐Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and erythema multiforme major (EM major) are severe dermatologic conditions characterized by varying degrees of skin detachment and involvement of mucosal membranes, often triggered by drug reactions or infections.
Sadaf Salehi, Pooneh Torabi, Mahsa Abbaspour, Nima Hajizadeh, Sara Sadeghi, Alireza Jafarzadeh, Azadeh Goodarzi   +6 more
wiley   +1 more source

Bilateral betrayal: When imaging calls out Vogt–Koyanagi–Harada’s one-eyed act

Indian Journal of Ophthalmology. Case Reports
We report a case of asymmetric Vogt-Koyanagi-Harada syndrome mimicking unilateral Central Serous Chorioretinopathy. This case highlights the diagnostic challenge for making a correct diagnosis between asymmetric Vogt-Koyanagi-Harada disease and Central ...
Shagun Korla, Gain C Rajput, Shreya Narang   +2 more
doaj   +1 more source