Results 71 to 80 of about 318,027 (338)
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma
Advanced Science, EarlyView.This study identifies USP10 as a novel deubiquitinase that antagonizes ferroptosis in head and neck squamous cell carcinoma (HNSCC). Mechanistically, USP10 directly stabilizes POLR2A protein through post‐translational deubiquitination, enabling POLR2A‐mediated transcriptional activation of SLC7A11, a key ferroptosis inhibitor.
Diekuo Zhang +13 more
wiley +1 more source
Automatic age detection in normal and pathological voice [PDF]
, 2015 Systems that automatically detect voice pathologies are usually trained with recordings belonging to population of all ages. However such an approach might be inadequate because of the acoustic variations in the voice caused by the natural aging process.
Castellanos Domínguez, Germán +3 more
core
Advanced Science, EarlyView.Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun +15 more
wiley +1 more source
Validation of the Swedish version of the Transsexual Voice Questionnaire Male-to-Female (TVQMtF) [PDF]
, 2014 A validated instrument that measures voice-related quality of life among transsexual male-to-females has previously been missing. The objective of the study was therefore to validate a Swedish translation of the Transsexual Voice Questionnaire Male-to ...
Hedberg, Jenny
core
Advanced Science, EarlyView.Human skin inherently forms a body‐coupled triboelectric circuit that enables the generation of triboelectric charges through contact between the skin surface and various materials. Integrated with an on‐finger, substrate‐free microfiber electrode, the material‐specific and personalized triboelectric signals can be imperceptibly collected for machine ...
Junting Huang +7 more
wiley +1 more source
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
Validity and Reliability of the Arabic Cough Severity Index
Laryngoscope Investigative OtolaryngologyObjectives This study aimed to translate and validate the Cough Severity Index (CSI) into Arabic (A‐CSI) and to evaluate its validity and reliability among patients with chronic cough.
Hamad F. Alrabiah +6 more
doaj +1 more source
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
The Efficacy of Telepractice in the Assessment and Treatment of Speech Disorders: A Systematic Review [PDF]
, 2019 Purpose: Children and adults with speech disorders face numerous barriers in accessing traditional face-to-face services with a speech-language pathologist. Telepractice may be a feasible solution. The aim of this systematic review was to investigate the
Cooley, Elizabeth +2 more
core +1 more source
Dysphonia secondary to traumatic avulsion of the vocal fold in infants [PDF]
, 2010 Objective: Airway compromise due to paediatric intubation injuries is well documented; however, intubation injuries may also cause severe voice disorders.
Bray, D +3 more
core +1 more source