Results 51 to 60 of about 922,036 (272)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Melissus and the Problem of the Void: Apology and/or Misapprehension of the Parmenidean Monism?
Peitho, 2017 With respect to Parmenides’ thought Melissus was regarded as a dissident thinker already in antiquity. His polemical introduction of the concept of void and the relative idea of infinite Being seemed particularly controversial.
Enrico Volpe
doaj +1 more source
Spatial and temporal tuning in void models for acceleration
, 2010 There has been considerable interest in recent years in cosmological models in which we inhabit a very large, underdense void as an alternative to dark energy.
Foreman, Simon +3 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The Effects of Void on Natural Ventilation Performance in Multi-Storey Housing
Buildings, 2016 Enhancing natural ventilation performance in multi-storey housing is very important for the living environment in terms of health and thermal comfort purposes.
Fakhriah Muhsin +3 more
doaj +1 more source
Computer Sciences & Mathematics Forum, 2023 The three-dimensional problem of the modelling of elastic wave propagation in a multi-layered acoustic metamaterial, a periodic elastic composite with periodic arrays of interface cracks or planar voids of arbitrary shape, is considered.
Mikhail V. Golub +4 more
doaj +1 more source
Coupled visco-mechanical and diffusion void growth modelling during composite curing [PDF]
, 2010 Most critical processing step during long fiber reinforced epoxy matrix composite laminate manufacturing is the polymerization stage. If not optimized, it gives birth to defects in the bulk material, such as voids.
Bernhart, Gérard +4 more
core +3 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source