Results 51 to 60 of about 932,648 (272)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Georesursy, 2017 The work is devoted to the study of cement type and composition of the Lower Triassic deposits of the Timan-Pechora province, their influence on reservoir properties of rocks.
N.N. Timonina
doaj +1 more source
A new dental casting technique for production of void-free dental models
European Oral Research, 2020 Purpose An essential of successful dental prosthesis is dental models. Voids present in dental models decreases accuracy and strength. This study investigates void formation in models fabricated by a new technique.
Nuran Özyemişci Cebeci +1 more
doaj +1 more source
, 2015 In astronomy, a void is an area in outer space which contains no galaxies. These are vast expanses of darkness and emptiness. This orchestral piece, simply titled void, attempts to describe such an area through various musical methods: long sustained ...
Aragon, Jared
core +2 more sources
Dynamics of Void and its Shape in Redshift Space
, 2011 We investigate the dynamics of a single spherical void embedded in a Friedmann-Lema\^itre universe, and analyze the void shape in the redshift space. We find that the void in the redshift space appears as an ellipse shape elongated in the direction of ...
A.G. Riess . +35 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A percolation-based micromechanical model for elastic stiffness and conductivity of foam concrete
Frontiers in Physics, 2023 Void morphology effect on percolation and even physico-mechanical performance of foam concrete is of great interest in the evaluation of service-life of civil and hydraulic infrastructures.
Fengjuan Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source