Results 61 to 70 of about 51,543 (309)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A Note on Optimal Design of Multiphase Elastic Structures

, 2014
The paper describes the first exact results in optimal design of three-phase elastic structures. Two isotropic materials, the "strong" and the "weak" one, are laid out with void in a given two-dimensional domain so that the compliance plus weight of a ...
Briggs, Nathan, Cherkaev, Andrej, Dzierzanowski, Grzegorz   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mechanical and Water Transport Characterization of Indian Almond – Banana Fibers Reinforced Hybrid Composites for Structural Applications

Journal of Natural Fibers, 2022
In this investigation, hybrid composites were prepared for structural applications using Indian almond and Banana fibers by hand layup method. Five types of composites were fabricated viz. I-I-I-I, I-B-B-I, I-B-I-B, B-I-I-B & B-B-B-B and the mechanical &
Anand Sundararaju Perinbakannan, Muralidharan Karuppusamy, Karuppasamy Ramar   +2 more
doaj   +1 more source

Spectral Properties of Galaxies in Void Regions

, 2015
We present a study of spectral properties of galaxies in underdense large-scale structures, voids. Our void galaxy sample (75,939 galaxies) is selected from the Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7) with $\rm z < 0.107$. We find that there
Constantin, Anca, Hao, Lei, Hoyle, Fiona, Liu, Chenxu, Pan, Danny, Vogeley, Micheal S.   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A review of void formation and its effects on the mechanical performance of carbon fiber reinforced plastic

Engineering Transactions, 2016
Carbon fiber reinforced plastic (CFRP) is ideal for high performance of mechanical properties. However, during the manufacturing process of CFRP, defects or flaws can easily be introduced into the material, among which void is the most common one.
Xueshu LIU, Fei CHEN
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Role of graphene nanoplatelets and carbon fiber on mechanical properties of PA66/thermoplastic copolyester elastomer composites

Materials Research Express, 2020
In this work, the effect of graphene nanoplatelets (GNPs) on the physico-mechnaical properties of short carbon fiber (SCF) reinforced polyamide 66/thermoplastic copolyester elastomer composites was investigated.
B Suresha, G Hemanth, R Hemanth, N P Lalla   +3 more
doaj   +1 more source