Results 151 to 160 of about 28,507,127 (275)

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

open access: yesAdvanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin   +9 more
wiley   +1 more source

Nondisruptive 3D profiling of combinations of epigenetic marks in single cells. [PDF]

open access: yesNat Methods
Chen Y   +8 more
europepmc   +1 more source

A 3D‐Printed SFE‐Graded Alloy Mitigates Cryogenic Discontinuous Plastic Flow and Hydrogen Embrittlement

open access: yesAdvanced Science, EarlyView.
A novel strategy features gradient composition and stacking fault energy‐tuned (CoCrMn)100‐2xFexNix fabricated via in situ alloying additive manufacturing. This design circumvents cryogenic discontinuous plastic flow and hydrogen embrittlement of metallic materials under quasi‐static loading and hydrogen‐rich environment relevant to lunar polar ...
Renhao Wu   +11 more
wiley   +1 more source

On the formation of superparamagnetic iron oxide nanoclusters. [PDF]

open access: yesRSC Adv
Schwarz P   +4 more
europepmc   +1 more source

A New Ordered Transformation‐Induced Plasticity Enables Exceptional Strength and Ductility in a B2 Medium‐Entropy Alloy

open access: yesAdvanced Science, EarlyView.
A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li   +8 more
wiley   +1 more source

Permanent Oxidative Dipole Engineering in Quinoline COFs for Boosting Exciton Dissociation and Oxygen Activation in H2O2 Photosynthesis

open access: yesAdvanced Science, EarlyView.
Permanent oxidative dipole (POD) engineering overcomes the electronic uniformity of quinoline‐linked COFs. By enhancing the dipole moment to 2.08 D and lowering exciton binding energy to 20.3 meV, it constructs a robust built‐in electric field and spatially decoupled redox centers. This bypasses inherent kinetic bottlenecks, achieving a 4569 µmol g−1 h−
Yong‐Quan Wu   +2 more
wiley   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

open access: yesAdvanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao   +10 more
wiley   +1 more source

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