Results 81 to 90 of about 11,059 (309)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

A new distal radius fracture classification depending on the specific fragments through machine learning clustering method

BMC Musculoskeletal Disorders
Purposes The objective of this study was to investigate intra-articular distal radius fractures, aiming to provide a comprehensive analysis of fracture patterns and discuss the corresponding treatment strategies for each pattern.
Yuling Gao, Yanrui Zhao, Yang Liu, Shan Lei, Hanzhou Wang, Yuerong Lizhu, Tianchao Lu, Zhexian Cheng, Dong Wang, Binzhi Zhao, Ziyi Li, Junlin Zhou   +11 more
doaj   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Mid-term functional outcome after the internal fixation of distal radius fractures [PDF]

, 2012
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Bradshaw, Lucy, Elliott, David S, Gallagher, Kieran, Newman, Kevin J, Phadnis, Joideep, Trompeter, Alex   +5 more
core   +2 more sources

Volar plate fixation of distal radius fractures

Turkish Journal of Trauma and Emergency Surgery, 2012
We aimed to evaluate the results of volar locking and unlocking plate fixation of adult distal radius fractures.Thirty-four patients (14 female, 20 male, mean age: 48.5 +/- 17.9 years) who were treated for distal radius fractures were investigated retrospectively.
Emrah Riza, Demirbaş, Ali Akin, Uğraş, Ibrahim, Kaya, Ibrahim, Sungur, Cemal, Kural, Ercan, Cetinus   +5 more
openaire   +3 more sources

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Fratura distal do rádio em pacientes com mais de 60 anos: placas ortogonais versus placa volar Distal radial fractures in patients over 60 years old: orthogonal plates versus volar plate

Revista Brasileira de Ortopedia, 2010
OBJETIVO: Comparar os resultados do tratamento cirúrgico entre placa volar com estabilidade angular e placas ortogonais em fraturas instáveis de rádio distal em pacientes com mais de 60 anos. MÉTODOS: Pacientes foram divididos em dois grupos tratados com
Edgard Novaes de França Bisneto, Emygdio José Leomil de Paula, Marcelo Rosa de Resende, Rames Mattar Júnior, Arnaldo Valdir Zumiotti   +4 more
doaj   +1 more source

Osseointegrated finger prostheses using a tripod titanium mini-plate [PDF]

, 2017
BACKGROUND: Digital amputation is a common upper extremity injury and can cause significant impairment in hand function, as well as psychosocial stigma.
Ciudad, Pedro, Doscher, Matthew, Galan, Ricardo, Liebling, Ralph, LO TORTO, Federico, Manrique, Oscar J   +5 more
core   +2 more sources

Miniaturized 3D Magnetic Force Sensor via Laser‐Assisted Folding and Magnetization for Enhanced Robotic Dexterity

Advanced Science, EarlyView.
To achieve 3D force sensing in confined spaces such as fingertips, we developed a laser‐assisted folding and magnetization method to fabricate miniature films with precise centripetal magnetization. The resulting compact sensor delivers high force resolution, rapid response, and long‐term stability, significantly enhancing the manipulation capabilities
Yujie Huang, Huangzhe Dai, Chengqian Zhang, Daofan Tang, Xinxin Zhang, Haonan Sun, Annan Ding, Xuebin Ni, Yizhi Zhang, Chengfeng Pan, Peng Zhao   +10 more
wiley   +1 more source