Mechanistic insights into volatile anesthetic modulation of K2P channels [PDF]
eLife, 2020 K2P potassium channels are known to be modulated by volatile anesthetic (VA) drugs and play important roles in clinically relevant effects that accompany general anesthesia.
Aboubacar Wague +9 more
doaj +3 more sources
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. [PDF]
PLoS ONE, 2019 The possibility that anesthesia during cancer surgery may affect cancer recurrence, metastasis, and patient prognosis has become one of the most important topics of interest in cancer treatment.
Chisato Sumi +7 more
doaj +3 more sources
Comparison of volatile anesthetic-induced preconditioning in cardiac and cerebral system: molecular mechanisms and clinical aspects [PDF]
European Journal of Medical Research, 2018 Volatile anesthetic-induced preconditioning (APC) has shown to have cardiac and cerebral protective properties in both pre-clinical models and clinical trials.
Shasha Chen +3 more
doaj +3 more sources
The neuroendocrine stress response compensates for suppression of insulin secretion by volatile anesthetic agents: An observational study [PDF]
Physiological Reports, 2023 Alterations in perioperative metabolic function, particularly hyperglycemia, are associated with increased post‐operative complications, even in patients without preexisting metabolic abnormalities.
William G. Tharp +4 more
doaj +2 more sources
Volatile Anesthetic Sevoflurane Attenuates Toll-Like Receptor 1/2 Activation. [PDF]
Anesth Analg, 2020 BACKGROUND: Although immunomodulatory effects of anesthetics have been increasingly recognized, their underlying molecular mechanisms are not completely understood. Toll-like receptors (TLRs) are one of the major receptors to recognize invading pathogens
Mitsui Y +5 more
europepmc +2 more sources
Use of Remifentanil for Open in utero Fetal Myelomeningocele Repair Maintains Uterine Relaxation with Reduced Volatile Anesthetic Concentration. [PDF]
Fetal Diagn Ther, 2020 Introduction: Open fetal repair of myelomeningocele (MMC) is an option for prenatally diagnosed spina bifida. Historically, high-dose volatile anesthetic was used for uterine relaxation but is associated with fetal cardiovascular depression.
Marsh BJ +4 more
europepmc +2 more sources
Surgical site infection after colorectal surgery according to the main anesthetic agent: a retrospective comparison between volatile anesthetics and propofol [PDF]
Korean Journal of Anesthesiology, 2016 BackgroundAnesthetic agents used for general anesthesia are emerging possible influential factors for surgical site infection (SSI). In this retrospective study, we evaluated the incidence of SSI after colorectal surgery according to the main anesthetic ...
Bon-Wook Koo +6 more
doaj +2 more sources
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes. [PDF]
Clin Pharmacol Ther, 2019 The identification in a patient of 1 of the 50 variants in the RYR1 or CACNA1S genes reviewed here should lead to a presumption of malignant hyperthermia susceptibility (MHS).
Gonsalves SG +14 more
europepmc +2 more sources
FASEB J, 2019 Sepsis remains a significant health care burden, with high morbidities and mortalities. Patients with sepsis often require general anesthesia for procedures and imaging studies. Knowing that anesthetic drugs can pose immunomodulatory effects, it would be
Koutsogiannaki S +7 more
europepmc +2 more sources
The Impact of Volatile Anesthetic Choice on Postoperative Outcomes of Cardiac Surgery: A Meta-Analysis. [PDF]
Biomed Res Int, 2017 Objectives To evaluate the impact of volatile anesthetic choice on clinically relevant outcomes of patients undergoing cardiac surgery. Methods Major databases were systematically searched for randomized controlled trials (RCTs) comparing volatile ...
Zorrilla-Vaca A +3 more
europepmc +2 more sources