Results 61 to 70 of about 24,266 (288)

A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. [PDF]

PLoS ONE, 2010
One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions. Induction of anesthesia is commonly attributed to drug-induced
Eliot B Friedman, Yi Sun, Jason T Moore, Hsiao-Tung Hung, Qing Cheng Meng, Priyan Perera, William J Joiner, Steven A Thomas, Roderic G Eckenhoff, Amita Sehgal, Max B Kelz   +10 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

Case Reports in Anesthesiology, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP).
Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan   +3 more
doaj   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

Brain Sciences, 2014
The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain ...
Sunny Chiao, Zhiyi Zuo
doaj   +1 more source

Type of anesthesia for cancer resection surgery: No differential impact on cancer recurrence in mouse models of breast cancer.

PLoS ONE, 2023
BackgroundSurgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use of propofol-based total intravenous anesthesia during cancer resection surgery is associated with improved ...
Julia Dubowitz, Alexandra I Ziegler, Richard Beare, Fabian Jost-Brinkmann, Adam K Walker, Ryan D Gillis, Aeson Chang, Ni-Chun Chung, Olga A Martin, Frédéric Hollande, Bernhard Riedel, Erica K Sloan   +11 more
doaj   +1 more source

Advances in Oncoanaesthesia and Cancer Pain

Cancer Treatment and Research Communications, 2021
Introduction:: The growing interest on how peri-‑operative interventions, especially regional anesthesia, during cancer surgery can alter oncological outcome increasing disease free survival is probably responsible for the birth of the new subspecialty ...
Mary Thomas
doaj   +1 more source

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Phase transitions in biological membranes

, 2018
Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung ...
A Blicher, A Blicher, A Gonzalez-Perez, A Gonzalez-Perez, A Hac, A Punnia-Moorthy, AG Lee, AL Hodgkin, AL Hodgkin, B Lautrup, D Johnston, D Papahadjopoulos, DB Mountcastle, DP Kharakoz, E London, EF DeLong, FH Johnson, FH Johnson, GH Kim, GS Manning, H Ebel, H Kamaya, H Kamaya, H Kamaya, H Träuble, HJ Galla, HM Seeger, HM Seeger, I Tasaki, J Gallaher, J Marmur, JE Rothman, JE Rothman, JLCM Vossenberg van de, JM Ritchie, JR Hazel, JR Hazel, JR Trudell, K Græsbøll, K Iwasa, K Iwasa, K Simons, KA Zecchi, KR Laub, L Onsager, LD Mosgaard, LD Mosgaard, LO Ingram, M Gudmand, M Moldovan, MC Sabra, MJ Halsey, MJ Pringle, OG Mouritsen, P Grabitz, PF Almeida, PL Privalov, R Böckmann, R Ravindra, R Winter, RS Cantor, RS Cantor, RW Glaser, S Johnson, SV Avery, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Horishita, Tian Wang, UR Pedersen, Y Kaminoh, Y Zuo   +76 more
core   +1 more source

Perioperative Neurocognitive Disorder: State of the Preclinical Science. [PDF]

, 2020
The purpose of this article is to provide a succinct summary of the different experimental approaches that have been used in preclinical postoperative cognitive dysfunction research, and an overview of the knowledge that has accrued. This is not intended
Culley, Deborah J, Eckenhoff, Maryellen F, Eckenhoff, Roderic G, Goodlin, Sarah J, Maze, Mervyn, Orser, Beverley A, Terrando, Niccolò, Wei, Huafeng, Whittington, Robert A, Xie, Zhongcong, Zuo, Zhiyi   +10 more
core