Results 61 to 70 of about 660,206 (287)

A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. [PDF]

PLoS ONE, 2010
One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions. Induction of anesthesia is commonly attributed to drug-induced
Eliot B Friedman, Yi Sun, Jason T Moore, Hsiao-Tung Hung, Qing Cheng Meng, Priyan Perera, William J Joiner, Steven A Thomas, Roderic G Eckenhoff, Amita Sehgal, Max B Kelz   +10 more
doaj   +1 more source

The volatile anesthetic isoflurane induces ecto-5′-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury

Kidney International, 2013
The volatile anesthetic isoflurane protects against renal ischemia and reperfusion injury by releasing renal tubular TGF-β1. Since adenosine is a powerful cytoprotective molecule, we tested whether TGF-β1 generated by isoflurane induces renal tubular ...
Mihwa Kim, Ahrom Ham, Joo Yun Kim, K. Brown, V. D’Agati, H. Lee   +5 more
semanticscholar   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, EarlyView.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Volatile anesthetics affect macrophage phagocytosis

PLOS ONE, 2019
Perioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial eradication. We examined the effect of commonly used anesthetics on macrophage phagocytosis and its mechanism.The effect of anesthetics (isoflurane, sevoflurane, propofol) on macrophage phagocytosis was
Nathan Blazon-Brown, Renyu Liu, Weiming Bu, Erika Matsunami, Erika Matsunami, Hasan Babazada, Lifei Hou, Lifei Hou, Koichi Yuki, Koichi Yuki, Sophia Koutsogiannaki, Sophia Koutsogiannaki, Hui Zha, Hui Zha, Hui Zha, Kirsten C. Odegard, Kirsten C. Odegard, Roderic G. Eckenhoff   +17 more
openaire   +4 more sources

Insights into Distinct Modulation of α7 and α7β2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane*

Journal of Biological Chemistry, 2013
Background: What determines hypersensitivity or insensitivity of β2-containing or α7 nAChRs to volatile anesthetics remains unclear. Results: Isoflurane binds to the EC end of the TM domain, modulates channel dynamics, and inhibits channel current in β2 ...
D. Mowrey, Qiang Liu, V. Bondarenko, Qiang Chen, E. Seyoum, Yan Xu, Jie Wu, P. Tang   +7 more
semanticscholar   +1 more source

Strong and Fatigue‐Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot‐Stretching for Tendon Repair

Advanced Science, EarlyView.
An anisotropic hydrogel (AHs) is prepared in this study. The strength of AHs can reach up to 33.14 ± 2.05 MPa, and it exhibits unique defect‐insensitive characteristics. Cracks can only deflect along the fiber alignment direction, demonstrating an interesting self‐protection function.
Huamin Li, Ying Zhang, Haidi Wu, Zhanqi Liu, Cheng Guan, Jin Zhang, Jingyi Chen, Shaohua He, Xuewu Huang, Wancheng Gu, Yiu Wing Mai, Jiefeng Gao   +11 more
wiley   +1 more source

Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration

Advanced Science, EarlyView.
The supramolecular lubricating hydrogel microspheres can provide stable mechanophysical protection at damaged matrix through interfacial hydration lubrication: in the early and middle stages, microspheres can actively provide microscale supramolecular lubrication (µ ≈ 0.04) for damaged matrix; in the late stage, the wear debris induced by shear and ...
Hui Yuan, Pengcheng Xiao, Wei Huang, Wenguo Cui   +3 more
wiley   +1 more source

Ischemia-Reperfusion Injury and Volatile Anesthetics [PDF]

BioMed Research International, 2014
Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure.
openaire   +3 more sources

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Volatile anesthetics and ischemia-reperfusion injury [PDF]

Korean Journal of Anesthesiology, 2015
Ischemia-reperfusion (IR) injury can occur under various clinical conditions in which the restoration of blood and oxygen to ischemic tissues results in a massive release of oxygen free radicals. For example, cardiac surgery, stroke, tourniquet application for orthopedic surgery, organ transplantation, and restoration of shock can cause IR injury ...
openaire   +4 more sources