Results 231 to 240 of about 1,098,953 (338)

Hidden patterns in volcanic seismicity: deep learning insights from Mt. Etna's 2020-2021 activity. [PDF]

Sci Rep
Abed W, Zali Z, Sciotto M, Cocina O, Cannata A, Picozzi M, Martínez-Garzón P, Vuan A, Saraò A, Sugan M.   +9 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

An introduction to global volcanic hazard and risk

, 2015
S. Loughlin, C. Vye-Brown, R. Sparks, S. Brown, J. Barclay, E. Calder, E. Cottrell, G. Jolly, J. Komorowski, C. Mandeville, C. Newhall, J. L. Palma, S. Potter, G. Valentine   +13 more
semanticscholar   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Complex eruption processes and deposits of basaltic fissures: insights from the ~37 ka Budj Bim volcanic complex, Southeastern Australia. [PDF]

Bull Volcanol
Kavanagh JL, Chamberlain KJ, Hrintchuk JA, Mariani E, Boyce J, Urbani S, Havard TA, Williams KM, Cas RAF.   +8 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Shape evolution of pumice during granular flow. [PDF]

Commun Earth Environ
Figueiredo C, Kueppers U, Pereira L, Depauli L, Esenyel S, Dingwell DB.   +5 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Fine ash from the Campanian Ignimbrite super-eruption, ~ 40 ka, southern Italy: implications for dispersal mechanisms and health hazard. [PDF]

Sci Rep
Gianchiglia F, Ballirano P, Giaccio B, Koutsodendris A, Nomade S, Pacella A, Palladino DM, Pross J, Veres D, Sottili G.   +9 more
europepmc   +1 more source