Results 61 to 70 of about 24,110 (329)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Detection of Volcanic Plumes by GPS: the 23 November 2013 Episode on Mt. Etna

Annals of Geophysics, 2015
The detection of volcanic plumes produced during explosive eruptions is important to improve our understanding on dispersal processes and reduce risks to aviation operations.
Massimo Aranzulla, Flavio Cannavò, Simona Scollo   +2 more
doaj   +1 more source

PlumeTraP: A New MATLAB-Based Algorithm to Detect and Parametrize Volcanic Plumes from Visible-Wavelength Images

Remote Sensing, 2022
Tephra plumes from explosive volcanic eruptions can be hazardous for the lives and livelihoods of people living in the proximity of volcanoes. Monitoring and forecasting tephra plumes play essential roles in the detection, characterization and hazard ...
Riccardo Simionato, Paul A. Jarvis, Eduardo Rossi, Costanza Bonadonna   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Sea-floor tectonics and submarine hydrothermal systems [PDF]

, 2005
The discovery of metal-depositing hot springs on the sea floor, and especially their link to chemosynthetic life, was among the most compelling and significant scientific advances of the twentieth century. More than 300 sites of hydrothermal activity and
de Ronde, Cornell D. J., Hannington, Mark D., Petersen, Sven   +2 more
core   +1 more source

Ozone depletion in tropospheric volcanic plumes [PDF]

Geophysical Research Letters, 2010
We measured ozone (O3) concentrations in the atmospheric plumes of the volcanoes St. Augustine (1976), Mt. Etna (2004, 2009) and Eyjafjallajökull (2010) and found O3 to be strongly depleted compared to the background at each volcano. At Mt. Etna O3 was depleted within tens of seconds from the crater, the age of the St. Augustine plumes was on the order
Vance, A, McGonigle, AJS, AIUPPA, Alessandro, Stith, JL, Turnbull, K, Von Glasow, R.   +5 more
openaire   +3 more sources

Photocatalytic Water Splitting on the Lunar Surface: Prospects for In Situ Resource Utilization

Advanced Materials Interfaces, EarlyView.
Water has been found in craters on the moon nearby locations which are illuminated >80% of the time. Photocatalysis uses energy from sunlight to drive chemical reactions such as water splitting to produce oxygen and hydrogen. It is a scalable technology that requires lighter equipment and utilizes resources available on the moon. ABSTRACT The discovery
Ranjani Kalyan, Thomas D. Small, Gregory F. Metha, Mahmoud Adel Hamza, Thomas J. O'Dea, Yideng Shen, Cameron J. Shearer   +6 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Weak degassing from remote Alaska volcanoes characterized with a new airborne imaging DOAS instrument and a suite of in situ sensors

Frontiers in Earth Science, 2023
Gas emissions from volcanoes occur when volatile species exsolve from magmatic and hydrothermal systems and make their way to the surface. Measurements of emitted gases therefore provide insights into volcanic processes. On 16 July 2021, we made airborne
Christoph Kern, Peter J. Kelly
doaj   +1 more source