Results 81 to 90 of about 145,392 (358)

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation

Advanced Science, EarlyView.
Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden, Craig J McClain, Zhongbin Deng   +11 more
wiley   +1 more source

Explosive volcanism, shock metamorphism and the K-T boundary [PDF]

The issue of whether shocked quartz can be produced by explosive volcanic events is important in understanding the origin of the K-T boundary constituents.
Desilva, S. L., Sharpton, V. L.
core   +1 more source

Compressive Strength of Volcanic Ash/Ordinary Portland Cement Laterized Concrete [PDF]

, 2010
This study investigates the effect of partial replacement of cement with volcanic ash (VA) on the compressive strength of laterized concrete. A total of 192 cubes of 150mm dimensions were cast and cured in water for 7, 14, 21, and 28 days of hydration ...
Olawuyi, B. J, Olusola, K. O
core   +2 more sources

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Using machine learning classifiers together with discrimination diagrams for validation of rock classification labels

Applied Computing and Geosciences
Rock classification based on chemical components is a common task in the geochemical domain. Literature recommends the Total Alkali and Silica (TAS) discrimination diagram for classifying igneous volcanic rocks by the sum of Na2O and K2O in relation to ...
Malte Mues, Dennis Kraemer, David M. Ernst Styn   +2 more
doaj   +1 more source

Venus: Geochemical conclusions from the Magellan data [PDF]

Though the Magellan mission was not designed to collect geochemical or petrological information, it has done so nonetheless. Since the time of the Pioneer Venus mission it has been known that high-altitude (greater than 2.5-5 km) mountainous areas on ...
Wood, J. A.
core   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Geological-morphological description of the Sedna and Guinevre planitiae on Venus (photomap sheets B-11, B-20, B-21) [PDF]

Presented are descriptions and maps of the region of Sedna and Guinevra Planitiae--representatives of the largest geological providense on Venus comprised of volcanic rock.
Bobina, N. N., Burba, G. A., Kadnichanskiy, S. A., Kotelnikov, V. A., Ostrovskiy, M. V., Petrov, G. M., Pronin, A. A., Rzhiga, O. N., Sidorenko, A. I., Tyuflin, Y. S.   +9 more
core   +1 more source

Boninite and Harzburgite from Leg 125 (Bonin-Mariana Forearc): A Case Study of Magma Genesis during the Initial Stages of Subduction [PDF]

, 1992
Holes drilled into the volcanic and ultrabasic basement of the Izu-Ogasawara and Mariana forearc terranes during Leg 125 provide data on some of the earliest lithosphere created after the start of Eocene subduction in the Western Pacific.
Arculus, Richard J., Ishii, Teruaki, Murton, Bramley J., Parkinson, Ian J., Pearce, Julian A., Peate, David W., van der Laan, Sieger R.   +6 more
core   +1 more source

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source