Results 121 to 130 of about 220,973 (314)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Monitoring volcanic activity at the Soufrière Volcano - A model for volcano monitoring operations in small-island nations

, 2018
Since its devastating eruption in 1902, the Soufrire volcano of St. Vincent has been kept under surveillance by a varied assemblage of local individuals and overseas-based scientists.
Robertson, Richard E. A. "et al."
core  

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Mitigation of human cognitive bias in volcanic eruption forecasting

Journal of Applied Volcanology
Modern operational eruption forecasting methods rely heavily on human judgment in the face of uncertainty and are thus susceptible to myriad cognitive biases and errors by the scientist-forecasters.
Heather M. N. Wright, Jeremy D. Pesicek, Stephen A. Spiller   +2 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Yellowstone Volcano Observatory

, 2010
This is the homepage of the United States Geological Survey's (USGS) Yellowstone Volcano Observatory. It features news articles, monitoring information, status reports and information releases, and information on the volcanic history of the ...

core  

Three-dimensional seismic velocity tomography of Montserrat from the SEA-CALIPSO offshore/onshore experiment

, 2010
The SEA-CALIPSO experiment in December 2007 incorporated a sea-based airgun source, and seismic recorders both on Montserrat and on the adjacent sea floor.
V. Voight, Malin., P., Kenedi, CL, D. Hidayat, Miller, V., Voight, V., C. L. Kenedi, R. S. J. Sparks, Minshull, T., Paulatto, M, Shalev, E, Minshull, T, Hidayat, Dannie., P. Malin, Paulatto, Michele, Mattioli, Glen., Minshull, T. A., Brown, L., Hidayat, D., Malin, P, Mattioli, G., Voight, B., Paulatto, M., V. Miller, Sparks, R.S.J., Kenedi, C. L., Kenedi, C., Hidayat, D, Sparks, RSJ, E. Shalev, Shalev, E., L. Brown, Kenedi, C.L., Malin, P., Miller, V, Sparks, R. S. J., T. Minshull, G. Mattioli, Mattioli, G, M. Paulatto, Voight, V, Brown, L   +41 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

On Volcanoes * [PDF]

Nature, 1870
openaire   +1 more source