Results 171 to 180 of about 360,893 (302)

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Correction: The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease. [PDF]

Front Immunol
Xi N, Xu X, Xu M, Wu N, Wu Y, Chen J, Liu S, Jiang L, Yan G, Zhang G, Liu Y.   +10 more
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Beyond Ubiquity: Scale-dependent patterns of tardigrade diversity on the Iztaccíhuatl volcano. [PDF]

PLoS One
Dueñas-Cedillo A, Armendáriz-Toledano F, Cancino-López RJ, García-Román J, Ruiz EA.   +4 more
europepmc   +1 more source

Magma production and growth of the lava dome of the Soufriere Hills Volcano, Montserrat, West Indies: November 1995 to November 1997 [PDF]

, 1998
A. M. Lejeune, Anderson, B. Darroux, Barclay, C. Harford, Cole, Devine, E. S. Calder, G. Norton, G. Skerrit, G. Wadge, J. Barclay, J. Toothill, M. A. Davies, M. James, M. V. Stasiuk, Murphy, N. S. Stevens, Nakada, Newhall, P. Cole, Pyle, R. Herd, R. S. J. Sparks, R. Watts, Robertson, S. Loughlin, S. R. Young, Sparks, Stasiuk, Swanson, T. H. Druitt, Young   +32 more
core   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Spatial transcriptomic profiling reveals body site-specific inflammatory differences in psoriasis lesions. [PDF]

Front Immunol
Emmanuel T, Ben Abdallah H, Nielsen MM, Ignatov B, Baez E, Andersen AS, Waaben L, Boye M, Kaaber I, Boonen DS, Petersen SR, Steiniche T, Bregnhøj A, Eidsmo L, Iversen L, Vestergaard C, Johansen C.   +16 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

A volcano reawakens after more than 100,000 years of "silent" magma reservoir growth. [PDF]

Sci Adv
Popa RG, Bachmann O, Guillong M, Giuliani A.   +3 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source