Results 51 to 60 of about 242,577 (288)

Automatic Classification of Volcano Seismic Signatures

Journal of Geophysical Research: Solid Earth, 2018
The prediction of volcanic eruptions and the evaluation of associated risks remain a timely and unresolved issue. This paper presents a method to automatically classify seismic events linked to volcanic activity.
Marielle Malfante, M. Dalla Mura, J. Mars, J. Métaxian, O. Macedo, A. Inza   +5 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Linking Subsurface to Surface Using Gas Emission and Melt Inclusion Data at Mount Cleveland Volcano, Alaska

Geochemistry, Geophysics, Geosystems, 2020
Mount Cleveland is one of Alaska's most active volcanoes, yet little is known about the magmatic system driving persistent and dynamic volcanic activity.
C. Werner, D. J. Rasmussen, T. Plank, P. J. Kelly, C. Kern, T. Lopez, J. Gliss, J. A. Power, D. C. Roman, P. Izbekov, J. Lyons   +10 more
doaj   +1 more source

Taking the pulse of Mars via dating of a plume-fed volcano

Nature Communications, 2017
Mars hosts the solar system’s largest volcanoes. Although their size and impact crater density indicate continued activity over billions of years, their formation rates are poorly understood.
B. E. Cohen, D. Mark, W. Cassata, Martin R. Lee, T. Tomkinson, Caroline L. Smith   +5 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A generalized deep learning model to detect and classify volcano seismicity

Volcanica
Volcano seismicity is often detected and classified based on its spectral properties. However, the wide variety of volcano seismic signals and increasing amounts of data make accurate, consistent, and efficient detection and classification challenging ...
David Fee, Darren Tan, John Lyons, Mariangela Sciotto, Andrea Cannata, Alicia Hotovec-Ellis, Társilo Girona, Aaron Wech, Diana Roman, Matthew Haney, Silvio De Angelis   +10 more
doaj   +1 more source

Pyroclastic density currents associated with the 2015 phreatomagmatic eruption of the Kuchinoerabujima volcano

Earth, Planets and Space, 2018
A pyroclastic density current (PDC) was observed with the phreatomagmatic eruption of the Kuchinoerabujima volcano, southern Japan, on May 29, 2015. The PDC flowed down in all direction from the source crater, forming three major branches.
Nobuo Geshi, Jun’ichi Itoh
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source