Results 51 to 60 of about 336,011 (301)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

News from Academy Bay [PDF]

open access: yes, 1993
Ecología de los Chivos Ferales (Capra hircus) en el Volcán Alcedo. Ecology of Feral Goats (Capra hircus) on Alcedo Volcano.
Merlen, Godfrey, Muñoz, Edgar
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

On the phenomena of volcanoes [PDF]

open access: yesAbstracts of the Papers Printed in the Philosophical Transactions of the Royal Society of London
In a paper on the Decomposition of the Earths, published in the Philosophical Transactions for 1812, the author offered it as a conjecture that the metals of the alkalies and earths might exist in the interior of the globe, and on being exposed to the action of air and water, give rise to volcanic fire and to the production of lavas; by the slow ...
openaire   +5 more sources

Tate-Shafarevich groups of constant elliptic curves and isogeny volcanos [PDF]

open access: yes, 2019
We describe the structure of Tate-Shafarevich groups of a constant elliptic curves over function fields by exploiting the volcano structure of isogeny graphs of elliptic curves over finite ...
Creutz, Brendan, Voloch, Jose Felipe
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

The Volcano of Colima [PDF]

open access: yesScientific American, 1903
n ...
openaire   +1 more source

Characterization of LUSI Mud as Geopolymer Raw Material [PDF]

open access: yes, 2012
The mud of mud volcano samples were collected from an eruption site named ‘LUSI’ (Lumpur “mud” –Sidoarjo), East Java, Indonesia for characterization. Analysis showed that, the major constituents of mud are SiO2 and Al2O3 which are higher than those in ...
Hardjito, D.   +4 more
core  

Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments

open access: yesFEBS Open Bio, EarlyView.
Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau   +3 more
wiley   +1 more source

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