Results 51 to 60 of about 220,973 (314)

Study on Radioactivity Components, Water Quality and Microstructure Characteristic of Volcano Ash as Geopolymer Artificial Aggregate [PDF]

, 2013
The assessments of radioactivity, water quality testing and microstructure characteristic of volcano ash have been examined. The measurement of the 226Ra, 232Th, 40K, and 238U were carried out using radioactive concentration value.
Nizar, I. Khairul, Bakri, A. M. Mustafa Al, Sandu, Ion, Yahya, Zarina, Rafiza, A. R., Hardjito, Djwantoro, Kamarudin, H.   +6 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Linking Subsurface to Surface Using Gas Emission and Melt Inclusion Data at Mount Cleveland Volcano, Alaska

Geochemistry, Geophysics, Geosystems, 2020
Mount Cleveland is one of Alaska's most active volcanoes, yet little is known about the magmatic system driving persistent and dynamic volcanic activity.
C. Werner, D. J. Rasmussen, T. Plank, P. J. Kelly, C. Kern, T. Lopez, J. Gliss, J. A. Power, D. C. Roman, P. Izbekov, J. Lyons   +10 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Surface temperature measurements of active lava flows on Kilauea volcano, Hawai'i. [PDF]

, 2002
Systematic hand-held radiometer measurements of lava surface temperatures in active flows and tubes on Kilauea volcano, Hawai′i reveal complexities that cannot be resolved in remotely sensed data from aircraft or satellites.
Pinkerton, Harry, Jones, Alun, James, Mike   +2 more
core  

Use of a portable topographic mapping millimetre wave radar at an active lava flow. [PDF]

, 2006
A ground-based millimetre wave radar, AVTIS (All-weather Volcano Topography Imaging Sensor), has been developed for topographic monitoring. The instrument is portable and capable of measurements over ranges up to ∼7 km through cloud and at night.
James, M R, Macfarlane, D. G., Pinkerton, H., Robertson, D. A., Macfarlane, D G, Robertson, D A, Wadge, G., Wadge, G, Pinkerton, H, James, M. R.   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Gas slug ascent through changes in conduit diameter : Laboratory insights into a volcano-seismic source process in low-viscosity magmas. [PDF]

, 2006
Seismic signals generated during the flow and degassing of low-viscosity magmas include long-period (LP) and very-long-period (VLP) events, whose sources are often attributed to dynamic fluid processes within the conduit.We present the results of ...
Lane, Steve J., James, M. R., Chouet, B. A.   +2 more
core  

A generalized deep learning model to detect and classify volcano seismicity

Volcanica
Volcano seismicity is often detected and classified based on its spectral properties. However, the wide variety of volcano seismic signals and increasing amounts of data make accurate, consistent, and efficient detection and classification challenging ...
David Fee, Darren Tan, John Lyons, Mariangela Sciotto, Andrea Cannata, Alicia Hotovec-Ellis, Társilo Girona, Aaron Wech, Diana Roman, Matthew Haney, Silvio De Angelis   +10 more
doaj   +1 more source