Results 81 to 90 of about 256,624 (343)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Distribution of Volcanoes [PDF]

Nature, 1873
SOME of the correspondence in your paper has latterly been So caustic, that timid people may be pardoned for shrinking from writing letters which bring down upon them the hammers of scorn and contempt so vigorously.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Volcano plots in hydrogen electrocatalysis – uses and abuses

Beilstein Journal of Nanotechnology, 2014
Summary Sabatier’s principle suggests, that for hydrogen evolution a plot of the rate constant versus the hydrogen adsorption energy should result in a volcano, and several such plots have been presented in the literature.
P. Quaino, Fernanda Juarez, E. Santos, W. Schmickler   +3 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tube coalescence in the Jingfudong lava tube and implications for lava flow hazard of Tengchong volcanism

International Journal of Speleology, 2016
Tube-fed structure occurs as a general phenomenon in Tengchong basic lavas, such as lava tubes, lava plugs and tube-related collapse depressions. We deduced the development of Laoguipo lava flows, which is the longest lava tube (Jingfudong lava tube ...
Zhengquan Chen, Yongshun Liu, Haiquan Wei, Jiandong Xu, Wenfeng Guo   +4 more
doaj   +1 more source

Geomechanical rock properties of a basaltic volcano

Frontiers in Earth Science, 2015
In volcanic regions, reliable estimates of mechanical properties for specific volcanic events such as cyclic inflation-deflation cycles by magmatic intrusions, thermal stressing, and high temperatures are crucial for building accurate models of volcanic ...
L. Schaefer, J. Kendrick, T. Oommen, Y. Lavallée, G. Chigna   +4 more
semanticscholar   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Planet Image-Based Inventorying and Machine Learning-Based Susceptibility Mapping for the Landslides Triggered by the 2018 Mw6.6 Tomakomai, Japan Earthquake

Remote Sensing, 2019
The 5 September 2018 (UTC time) Mw6.6 earthquake of Tomakomai, Japan has triggered about 10,000 landslides with high density, causing widespread concern.
Xiaoyi Shao, Siyuan Ma, Chong Xu, Pengfei Zhang, Boyu Wen, Yingying Tian, Qing Zhou, Yulong Cui   +7 more
doaj   +1 more source